{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:27Z","timestamp":1753878387366,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Digitalis glycosides are employed for rate control of atrial fibrillation and treatment of heart failure. Previous studies suggested potential harmful effects of digitalis therapy. The aim of the present study was to assess the prevalence and potential impact of digitalis therapy on outcomes in patients with systolic failure who were implanted with an ICD\u2010 or CRT\u2010ICD system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The German Device Registry is a nationwide, prospective registry with a 1\u2010year follow\u2010up investigating 4384 patients receiving either ICD or CRT systems in 52 German centers. The present analysis focused on the presence of digitalis therapy in 3826 patients undergoing device implantation. Patients receiving digitalis therapy (<jats:italic>n<\/jats:italic>\u2009=\u2009800) presented a more severely impaired left ventricular function, higher NYHA class, and an increased incidence of left bundle branch block. Consequently, the implantation of CRT systems was more common in this group. One\u2010year mortality did not significantly differ between both groups (9.1% vs. 7.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.14). Similar results were obtained for the combined endpoint, including death, myocardial infarction, and stroke. ICD shock delivery (19.7% vs. 15.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.006) and device revision (11.4% vs. 7.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.004) were more common in digitalis\u2010treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study in patients undergoing ICD or CRT implantation, an association of digitalis therapy with an increased risk of device revision was observed. Of note, mortality or severe cardiovascular events did not differ between both groups. Furthermore, an increased risk of ICD shock delivery was observed in digitalis\u2010treated patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70080","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T03:49:46Z","timestamp":1743997786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Digitalis Therapy Is Associated With an Increased Risk of <scp>ICD<\/scp> Shock Delivery and Device Revision"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-9886","authenticated-orcid":false,"given":"Gerrit","family":"Frommeyer","sequence":"first","affiliation":[{"name":"Clinic for Cardiology II \u2013 Electrophysiology University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp S.","family":"Lange","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology II \u2013 Electrophysiology University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kleemann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Klinikum der Stadt Ludwigshafen  Ludwigshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Stellbrink","sequence":"additional","affiliation":[{"name":"Department of Cardiology Klinikum Bielefeld  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vivantes Klinikum Am Urban and Neuk\u00f6lln  Berlin Germany"},{"name":"Rostock University  Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Brachmann","sequence":"additional","affiliation":[{"name":"Medical School REGIOMED, University of Split School of Medicine  Split 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