{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:48:21Z","timestamp":1790138901001,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Atrial fibrillation (\n AF<\/jats:styled-content>\n ) is the most common sustained cardiac arrhythmia in adults, associated with serious cardiovascular complications such as ischemic stroke, heart failure, and myocardial infarction. Pulmonary vein isolation (\n PVI<\/jats:styled-content>\n ) is an established rhythm\u2010control strategy for\n AF<\/jats:styled-content>\n . Although the\n \n CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n <\/jats:styled-content>\n \u2010\n VASc<\/jats:styled-content>\n score is primarily used to estimate stroke risk in patients with\n AF<\/jats:styled-content>\n , its potential utility in predicting\n AF<\/jats:styled-content>\n recurrence after\n PVI<\/jats:styled-content>\n has not been fully explored in contemporary, real\u2010world multicenter settings.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To evaluate the association between the\n \n CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n <\/jats:styled-content>\n \u2010\n VASc<\/jats:styled-content>\n score and both\n AF<\/jats:styled-content>\n recurrence and adverse clinical outcomes following\n PVI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a retrospective cohort study using the Israeli Catheter Ablation Registry (\n ICAR<\/jats:styled-content>\n ), including 860 patients undergoing their first\n PVI<\/jats:styled-content>\n for\n AF<\/jats:styled-content>\n . Patients were grouped by\n \n CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n <\/jats:styled-content>\n \u2010\n VASc<\/jats:styled-content>\n score (0\u20131, 2\u20134, >\u20095). The primary endpoint was\n AF<\/jats:styled-content>\n recurrence within 12\u2009months. Secondary endpoints included re\u2010hospitalization, major adverse cardiovascular events (\n MACE<\/jats:styled-content>\n ), and all\u2010cause mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n AF<\/jats:styled-content>\n recurrence occurred in 32% of patients. Recurrence rates were 25.7%, 31.4%, and 51% across the low, intermediate, and high\n \n CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n <\/jats:styled-content>\n \u2010\n VASc<\/jats:styled-content>\n score groups, respectively. A higher score was independently associated with increased recurrence risk (\n HR<\/jats:styled-content>\n \u2009=\u20092.88; 95%\n CI<\/jats:styled-content>\n , 1.75\u20134.74;\n p<\/jats:italic>\n \u2009<\u20090.001). Elevated\n \n CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n <\/jats:styled-content>\n \u2010\n VASc<\/jats:styled-content>\n scores also correlated with higher\n MACE<\/jats:styled-content>\n and re\u2010hospitalization rates. No significant difference in all\u2010cause mortality was observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The\n \n CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n <\/jats:styled-content>\n \u2010\n VASc<\/jats:styled-content>\n score is an independent predictor of\n AF<\/jats:styled-content>\n recurrence and adverse outcomes after\n PVI<\/jats:styled-content>\n . Its simplicity, availability, and routine use make it a clinically useful tool to support preprocedural risk stratification in\n AF<\/jats:styled-content>\n patients undergoing ablation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/anec.70088","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:38:57Z","timestamp":1746689937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["\n CHA\n 2<\/sub>\n DS\n 2<\/sub>\n <\/scp>\n \u2010\n VASc<\/scp>\n Score as a Predictor for Atrial Fibrillation Recurrence and Clinical Outcomes Following Pulmonary Vein Isolation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-2727","authenticated-orcid":false,"given":"Mustafa","family":"Gabarin","sequence":"first","affiliation":[{"name":"Cardiology Department, Meir Medical Center, Kfar\u2010Saba and Sackler Faculty of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Suleiman","sequence":"additional","affiliation":[{"name":"Eyal Ofer Heart Hospital, Cardiac Electrophysiology and Pacing Rambam Health Care Campus Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Elias","sequence":"additional","affiliation":[{"name":"Eyal Ofer Heart Hospital, Cardiac Electrophysiology and Pacing Rambam Health Care Campus Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Marai","sequence":"additional","affiliation":[{"name":"Cardiology Department, Baruch Padeh Medical Center, the Azrieli Faculty of Medicine in the Galilee Bar\u2010Ilan University Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Beinart","sequence":"additional","affiliation":[{"name":"Heart Institute, Sheba Medical Center, Tel\u2010Hashomer, Israel and Sackler School of Medicine Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Nof","sequence":"additional","affiliation":[{"name":"Heart Institute, Sheba Medical Center, Tel\u2010Hashomer, Israel and Sackler School of Medicine Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Michowitz","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center Shaare Zedek Medical Center and Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Glikson","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center Shaare Zedek Medical Center and Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Konstantino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiac Electrophysiology and Pacing Soroka University Hospital, ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moti","family":"Haim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiac Electrophysiology and Pacing Soroka University Hospital, ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Luria","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hadassah Medical Organization and Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pereg","sequence":"additional","affiliation":[{"name":"Cardiology Department, Meir Medical Center, Kfar\u2010Saba and Sackler Faculty of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avishag","family":"Laish\u2010Farkash","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Electrophysiology and Pacing Unit Assuta Ashdod University Medical Center, ben\u2010Gurion University of the Negev Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Omelchenko","sequence":"additional","affiliation":[{"name":"Cardiology Department, Meir Medical Center, Kfar\u2010Saba and Sackler Faculty of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Israeli Working Group on Pacing Electrophysiology","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.064"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.05.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2022.06.052"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.12.034"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001182"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010015\u20100856\u2010x"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"S8","article-title":"A 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