{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:18:19Z","timestamp":1753877899358,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>QT interval corrected dispersion (QTcd) reflects the heterogeneity of ventricular repolarization and has been proposed as a marker for arrhythmic risk in various neurologic and cardiac conditions. The aim of this study was to evaluate QTcd differences between children with epilepsy and healthy controls, with attention to age and antiepileptic drug use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was conducted on 50 children with epilepsy and 50 age\u2010 and sex\u2010matched control children admitted to Shahid Beheshti Hospital in Kashan in 2019. QTcd was manually measured from 12\u2010lead electrocardiograms (ECGs). Data were analyzed using SPSS version 22.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No overall significant difference was observed in QTcd between groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). However, children with epilepsy under 5\u2009years of age had significantly higher QTcd than controls of the same age (<jats:italic>p<\/jats:italic>\u2009=\u20090.014). Moreover, QTcd was significantly lower in children with epilepsy receiving medication compared with those not on treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although overall QTcd did not differ significantly between epileptic and control children, age under five and antiepileptic drug use significantly influenced QTcd. These findings suggest the importance of cardiac evaluation and early treatment in younger patients with epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/anec.70094","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:50:04Z","timestamp":1747741804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>QTc<\/scp> Interval Dispersion in Pediatric Epilepsy: A Case\u2013Control Study From Iran"],"prefix":"10.1111","volume":"30","author":[{"given":"Ahmad","family":"Talebian","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Mohammad","family":"Shakiba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Malekipoor","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit Shahid Beheshti Hospital, Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Hafezipour","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-4995","authenticated-orcid":false,"given":"Mohammad Mahdi","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Talebian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Gilasi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.3.346"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1406"},{"issue":"18","key":"e_1_2_11_4_1","first-page":"3508","article-title":"Two Markers in Predicting the Cardiovascular Events in Patients With Polycystic Ovary Syndrome: Increased P\u2010Wave and QT Dispersion","volume":"19","author":"Akdag S.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13286"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00298.2019"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.1997.tb00325.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12253"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6960810"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311170"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.12.011"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"volume-title":"Atlas: Epilepsy Care in the World","year":"2005","author":"GCa E.","key":"e_1_2_11_13_1"},{"issue":"585","key":"e_1_2_11_14_1","first-page":"2","article-title":"Usefulness of Measuring QT Dispersion for Anesthesia and Surgical Procedures","volume":"6","author":"Hamaguchi S.","year":"2015","journal-title":"Journal of Anesthesia & Clinical Research"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0221-2"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951111001867"},{"issue":"2","key":"e_1_2_11_17_1","first-page":"31","article-title":"The Prognostic Value of QT Dispersion in Patients Presenting With Acute Neurological Events","volume":"15","author":"Lazar J.","year":"2008","journal-title":"Journal of Invasive Cardiology"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.09.006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2017.01.006"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.106192"},{"issue":"1","key":"e_1_2_11_21_1","first-page":"25","article-title":"Evaluation of QT Dispersion in Children With Breath Holding Spells","volume":"10","author":"Movahedian A. 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