{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:38:13Z","timestamp":1769582293381,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Left ventricular non\u2010compaction (LVNC) is a rare cardiomyopathy characterized by prominent trabeculations and deep recesses. Neonatal cases, particularly with severe metabolic disturbances, are uncommon. We report a 2\u2010day\u2010old neonate with LVNC and dilated cardiomyopathy, presenting recurrent heart failure associated with hyperkalemia, metabolic acidosis, hyperlactatemia, and hypoglycemia. Management included mechanical ventilation, metabolic correction, and heart failure therapy, leading to improved cardiac function. Genetic analysis revealed a de novo heterozygous pathogenic\n                    <jats:italic>ACTN2<\/jats:italic>\n                    deletion spanning exons 2\u20136. This case broadens the phenotypic spectrum of\n                    <jats:italic>ACTN2<\/jats:italic>\n                    \u2010related LVNC and suggests a potential link between metabolic disturbances and cardiac deterioration.\n                  <\/jats:p>","DOI":"10.1111\/anec.70117","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T18:19:52Z","timestamp":1768933192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["De Novo\n                    <scp>\n                      <i>ACTN2<\/i>\n                    <\/scp>\n                    Variant in a Chinese Neonate With Left Ventricular Non\u2010Compaction and Metabolic Disturbances: A Rare Case Report"],"prefix":"10.1111","volume":"31","author":[{"given":"Jinqiu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Pediatric Cardiac Center Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences\/Affiliated Cardiovascular Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Pediatric Cardiac Center Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences\/Affiliated Cardiovascular Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9824-9899","authenticated-orcid":false,"given":"Juxian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Pediatric Cardiac Center Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences\/Affiliated Cardiovascular Hospital of Kunming Medical University  Kunming 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of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.70117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anec.70117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.70117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:25:22Z","timestamp":1769534722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.70117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/anec.70117"],"URL":"https:\/\/doi.org\/10.1111\/anec.70117","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"value":"1082-720X","type":"print"},{"value":"1542-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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