{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:38:13Z","timestamp":1769582293300,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Implantable cardioverter\u2010defibrillators (ICD) are first\u2010line treatment to prevent sudden cardiac death due to recurrent ventricular tachycardia and fibrillation (VT\/VF). However, some patients with organic heart disease (OHD) die without ever receiving appropriate ICD therapy. This study aimed to identify predictors of death without appropriate ICD therapy in patients with OHD who received ICD or cardiac resynchronization therapy with a defibrillator (CRT\u2010D) for secondary prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed consecutive patients who received ICD\/CRT\u2010D for secondary prevention between 2000 and 2022. Patients without OHD or those alive without appropriate ICD therapy were excluded. The \u201cno\u2010benefit group\u201d included patients who died or developed severe disability without appropriate ICD therapy or those who died within 1\u2009year after their first appropriate therapy. The \u201cbenefit group\u201d included patients who survived &gt;\u20091\u2009year after appropriate therapy. Clinical characteristics were compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 170 patients analyzed (median follow\u2010up: 9.1\u2009years), 43 (25%) were classified into the no\u2010benefit group (30 died without appropriate therapy, 10 died within 1\u2009year of first appropriate therapy, and 3 developed severe disability without appropriate therapy). Multivariate analyses identified age &gt;\u200970\u2009years and history of VF as independent predictors of \u201cno benefit.\u201d Among patients with VF aged \u2265\u200970\u2009years, 71% were classified into the no\u2010benefit group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although 75% of patients benefited from ICD therapy for secondary prevention, elderly patients with VF may gain limited benefits from ICD implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anec.70131","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:46:01Z","timestamp":1765435561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Benefits of Implantable Cardioverter\u2013Defibrillator for Secondary Prevention in Patients With Organic Heart Disease"],"prefix":"10.1111","volume":"31","author":[{"given":"Rie","family":"Akagawa","sequence":"first","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-4221","authenticated-orcid":false,"given":"Sou","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minori","family":"Sakurazawa","sequence":"additional","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kato","sequence":"additional","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Furuse","sequence":"additional","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomasa","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Ikami","sequence":"additional","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1554-1056","authenticated-orcid":false,"given":"Yuki","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaomi","family":"Chinushi","sequence":"additional","affiliation":[{"name":"Niigata University School of Medicine  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Inomata","sequence":"additional","affiliation":[{"name":"Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.10.036"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711273372202"},{"key":"e_1_2_15_4_1","first-page":"1045","article-title":"Impact of Early Complications on Outcomes in Patients With Implantable Cardioverter\u2010Defibrillator for Primary Prevention","volume":"13","author":"Ascoeta M. 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