{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:57:22Z","timestamp":1783670242832,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>P\u2010wave parameters, readily obtainable from standard 12\u2010lead ECGs, have been associated with atrial fibrillation (AF), ischemic stroke, and other cardiovascular conditions. Left atrial cardiomyopathy (AtCM), characterized by atrial fibrosis and functional impairment, is considered a central substrate in the development of AF and embolic stroke of undetermined source. This study examines the relationship between P\u2010wave parameters and left atrial hemodynamics and evaluates their potential diagnostic utility in identifying AtCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a monocentric, prospective study in hospitalized patients. Inclusion criteria were sinus rhythm and age \u2265\u200918\u2009years. P\u2010wave parameters were assessed in conjunction with echocardiographic measures of left atrial function. Statistical analyses compared patients with and without pathological P\u2010wave parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 416 patients were included. Pathological P\u2010wave parameters were highly prevalent, with 55% of patients exhibiting \u2265\u20093 abnormalities. Advanced interatrial block (IAB) showed a robust association with impaired left atrial hemodynamics, whereas other parameters, such as PTFV1, demonstrated only weak correlations. Patients with advanced IAB exhibited significant alterations in left atrial size, function, and NT\u2010proBNP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Advanced IAB emerged as the most reliable P\u2010wave parameter for detecting left atrial dysfunction in AtCM, whereas other P\u2010wave indices, including PTFV1, were less informative. These findings highlight the diagnostic value of advanced IAB in identifying AtCM, particularly in patients with embolic stroke of undetermined source, and emphasize the need for more refined diagnostic criteria in future investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anec.70145","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:39:23Z","timestamp":1766129963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of P\u2010Wave Parameters With Left Atrial Hemodynamics in Atrial Cardiomyopathy"],"prefix":"10.1111","volume":"31","author":[{"given":"Melissa","family":"Kazantzi","sequence":"first","affiliation":[{"name":"Department of Cardiology and Rhythmology University Hospital St. Josef Hospital  Bochum 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