{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:21:52Z","timestamp":1780964512710,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between 24\u2010h minimum heart rate (MHR) and deceleration capacity (DC) in patients with type 2 diabetes mellitus (T2DM) and essential hypertension (EH) and to explore DC differences across sex\u2010stratified MHR categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center cross\u2010sectional study, 123 patients with T2DM and EH were stratified by sex\u2010specific 24\u2010h MHR thresholds (reduced\/normal\/elevated) based on previous studies. DC and heart rate variability (HRV) indices were derived from 24\u2010h Holter recordings. Bivariate correlation analysis was performed to examine the relationship between MHR and DC. Subsequently, multiple linear regression analysis was conducted with DC as the dependent variable to identify independent predictors of DC. Demographics, HRV indices, echocardiographic parameters, and laboratory findings were included as independent variables. Subgroup analyses stratified by sex and MHR categories were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MHR showed a significant negative correlation with DC (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.484,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Stepwise multiple linear regression identified age (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.264,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), MHR (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.320,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and SDNN_INDX (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.316,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) as independent DC predictors. Sex\u2010MHR subgroup analysis revealed: In Group B (normal MHR), age predicted reduced DC in both sexes (males:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.375,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041; females:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.612,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). In Group C (elevated MHR), SDNN_INDX correlated with higher DC in both sexes (males:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.363,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027; females:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.808,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). MHR negatively impacted DC only in males with elevated MHR (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.386,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Age predicts reduced DC within normal MHR ranges, while preserved SDNN_INDX correlates with higher DC in elevated MHR subgroups. This sex\u2010 and MHR\u2010stratified approach enables personalized risk stratification in T2DM and EH patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anec.70189","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:40:38Z","timestamp":1776318038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation Analysis of 24\u2010h Minimum Heart Rate Levels and Deceleration Capacity of Heart Rate in Patients With Type 2 Diabetes Mellitus Complicated With Essential Hypertension"],"prefix":"10.1111","volume":"31","author":[{"given":"Pingping","family":"Wu","sequence":"first","affiliation":[{"name":"Department of General Medicine The First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengrong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Medicine The First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of General Medicine The First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linying","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of General Medicine Zhanggang Street Community Health Service Center  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of General Medicine The First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Medicine The First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9890-4482","authenticated-orcid":false,"given":"Qunfang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of General Medicine The First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-012-9424-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-S002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68735-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195166"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.19"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)93323-0"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2023.2177371"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016075"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs449"},{"issue":"4","key":"e_1_2_12_12_1","first-page":"224","article-title":"Cardiac Autonomic Dysfunctions in Type 2 Diabetes Mellitus: An Investigative Study With Heart Rate Variability Measures","volume":"12","author":"John A. 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