{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:59:28Z","timestamp":1790312368519,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R21HL172209"],"award-info":[{"award-number":["R21HL172209"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The electrocardiogram (ECG) is a low\u2010cost, readily available test that may detect dysrhythmia, chamber enlargement, and ischemia in an acquired heart disease population. Use of resting ECG to predict adverse events in an adult congenital heart disease (ACHD) population is unknown. ECG characteristics, outcomes, and vital status of 8130 adults born between 1945 and 2001 with at least two available ECGs during a 10\u2010year surveillance period (2010\u20132019) were evaluated at baseline and at the end of surveillance. Outcomes included cardiac hospitalizations, cardiac surgery or intervention, or death during surveillance. Broad CHD anatomic groups were analyzed as follows: \u201c\n                    <jats:italic>left<\/jats:italic>\n                    \u2010sided,\u201d \u201c\n                    <jats:italic>right<\/jats:italic>\n                    \u2010sided,\u201d \u201c\n                    <jats:italic>single<\/jats:italic>\n                    \u2010\n                    <jats:italic>ventricle<\/jats:italic>\n                    ,\u201d and \u201c\n                    <jats:italic>neither<\/jats:italic>\n                    \u201d to account for differences in loading conditions. Of the cohort, 7.2% died, and 33.0% remained alive without adverse events. ECG parameters associated with mortality include wider QRS duration (QRSd), longer corrected QT (QTc), greater QRS\u2010T angle, left bundle branch block, and rhythm change. Those who died had longer mean baseline QRSd (107.3\u2009ms vs. 101.83\u2009ms,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and QTc (434.94\u2009ms vs. 425.20\u2009ms,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0004). Change in QRSd (\u2206QRSd) was greater in the deceased group than alive (5.18\u2009ms vs. 2.01\u2009ms,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), and in alive with an adverse event compared to those alive without an event (2.78\u2009ms vs. 0.42\u2009ms,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Mean QRS\u2010T angle remained concordant in those without an adverse event but deviated in the adverse event group (5.65\u00b0 vs. 22.91\u00b0) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). ECG characteristics and changes over time are associated with adverse cardiac events and mortality in a CHD population. Further study is needed to develop an ECG\u2010based risk model to identify at\u2010risk CHD patients.\n                  <\/jats:p>","DOI":"10.1111\/anec.70224","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:39:10Z","timestamp":1786973950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrocardiogram Characteristics and Outcomes in an Adult Congenital Heart Disease Population"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-0226","authenticated-orcid":false,"given":"Seyedeh Somayyeh","family":"Mousavi","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3301-0980","authenticated-orcid":false,"given":"Cheryl L.","family":"Raskind\u2010Hood","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1582-2642","authenticated-orcid":false,"given":"Alexandra","family":"Haffner","sequence":"additional","affiliation":[{"name":"School of Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Robichaux","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5882-2361","authenticated-orcid":false,"given":"Lindsey C.","family":"Ivey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-6825","authenticated-orcid":false,"given":"Reza","family":"Sameni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Emory University  Atlanta Georgia USA"},{"name":"Biomedical Engineering Department Georgia Institute of Technology  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-0329","authenticated-orcid":false,"given":"Wendy M.","family":"Book","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University  Atlanta Georgia USA"},{"name":"Division of Cardiology School of Medicine Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv519"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102016\u2010310068"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010043215"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029138"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.08.007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2025.01.005"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010274"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.09.010"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102022\u2010069531"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000354"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.2.231"},{"key":"e_1_2_11_13_1","unstructured":"GE Medical Systems Information Technologies.2011.\u201c510(k) Summary: MUSE Cardiology Information System. Premarket Notification Submission.\u201dhttps:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf11\/K110132.pdf."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12780"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102014\u2010306030"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.048"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12732"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.008121"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.03.021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010624"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106579\/ae1926"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20107120\u20103\u201013"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.11.012"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746\u2010024\u201001407\u2010y"},{"key":"e_1_2_11_25_1","unstructured":"Sameni R.2006\u20132025.\u201cThe Open\u2010Source Electrophysiological Toolbox (OSET) Version 4.0.\u201dhttps:\/\/github.com\/alphanumericslab\/OSET."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/21501351221111998"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542\u2010474X.2007.00195.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001402"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.027763"}],"container-title":["Annals of Noninvasive Electrocardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.70224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/anec.70224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/anec.70224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:17:55Z","timestamp":1790309875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/anec.70224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/anec.70224"],"URL":"https:\/\/doi.org\/10.1111\/anec.70224","archive":["Portico"],"relation":{},"ISSN":["1082-720X","1542-474X"],"issn-type":[{"value":"1082-720X","type":"print"},{"value":"1542-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70224"}}