{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:46:38Z","timestamp":1792133198601,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201000414"],"award-info":[{"award-number":["2019\u201000414"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2023\u201002652"],"award-info":[{"award-number":["2023\u201002652"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Noninvasive Electrocardiol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Chronic\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) infection may promote systemic inflammation and has been proposed as a contributor to atrial fibrillation (AF), but clinical evidence is inconsistent. The aim of the study was to explore whether active\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection was associated with AF in patients hospitalized with acute myocardial infarction (AMI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional analysis included adults from a two\u2010center observational AMI cohort. Active\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection was assessed during hospitalization using a urea breath test (UBT). AF was defined as AF documented before admission or identified during the index hospitalization. Associations were estimated using logistic regression adjusted for age, sex, center, and smoking. Exploratory multivariable interaction analyses were also performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 310 enrolled patients, 300 had conclusive\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      screening results; 60 (20.0%) were positive. AF was recorded in 4 of 60\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2010positive patients (6.7%) and 30 of 240\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2010negative patients (12.5%).\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      positivity was not significantly associated with recorded AF (unadjusted OR, 0.55; 95% CI, 0.17\u20131.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.228; adjusted OR, 0.54; 95% CI, 0.16\u20131.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.235). These estimates refer to pooled AF; only four AF cases occurred among patients testing positive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      No statistically significant association was detected between\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      breath\u2010test positivity and pooled documented AF among patients hospitalized with AMI, but a clinically meaningful association cannot be excluded. Larger prospective studies with longitudinal follow\u2010up are needed to clarify whether active\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection is associated with incident AF after AMI.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/anec.70245","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:07:23Z","timestamp":1792130843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Active\n                    <i>Helicobacter pylori<\/i>\n                    Infection and Atrial Fibrillation in Patients Hospitalized With Acute Myocardial Infarction"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2939-8306","authenticated-orcid":false,"given":"Mohammed","family":"Hashem","sequence":"first","affiliation":[{"name":"Department of Medicine Karolinska Institutet, Solna  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3750-6075","authenticated-orcid":false,"given":"Martin O.","family":"Sundqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, Division of Cardiology Karolinska Institutet, S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2127-070X","authenticated-orcid":false,"given":"Jonatan","family":"W\u00e4rme","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, Division of Cardiology Karolinska Institutet, S\u00f6dersjukhuset  Stockholm 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