{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:03:14Z","timestamp":1761292994116},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T00:00:00Z","timestamp":1358121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic influence of lateral neck nodal metastases present at the time of diagnosis of papillary thyroid cancer (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>) remains controversial. This study aims to document disease outcomes and nodal recurrence rates in such patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> and lateral neck nodal metastases who underwent concurrent total thyroidectomy, central and lateral compartment neck dissection between 2000 and 2010 were identified from the prospectively maintained surgical databases of The <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ydney and <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity of <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>isconsin <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ndocrine <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urgical <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nits. Disease outcomes and nodal recurrence rates were compared at 12 months post\u2010operatively and in longer\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During this 11\u2010year period, 121 patients were identified. Mean age was 45 years; 58% were female and 98% underwent post\u2010operative radioactive iodine ablation. At a median follow\u2010up of 31 months (range 12\u2013140), there were no disease\u2010specific deaths and disease\u2010free survival (defined by stimulated serum thyroglobulin (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>g) &lt; 2.0\u2009\u03bcg\/L, negative clinical and radiological examination) was 66%. Of the 50 patients with persistently elevated <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>g measured 12 months post\u2010operatively, 15 developed clinical lateral neck nodal recurrence. All have undergone re\u2010operative surgery. Elevated stimulated <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>g at 12 months post\u2010operatively and a nodal ratio of &gt;30% were significantly associated with an increased risk of lateral neck nodal recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With total thyroidectomy, formal compartmental neck dissection and radioactive iodine treatment, disease\u2010free survival can be achieved in the majority of patients with <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> and synchronous lateral neck nodal metastases. A persistently elevated <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>g post\u2010operatively and a high ratio of metastatic nodes identify patients at increased risk of locoregional recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12045","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T04:19:18Z","timestamp":1358223558000},"page":"240-244","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Disease outcomes and nodal recurrence in patients with papillary thyroid cancer and lateral neck nodal metastases"],"prefix":"10.1111","volume":"84","author":[{"given":"Christine J.","family":"O'Neill","sequence":"first","affiliation":[{"name":"Endocrine Surgical Unit The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Coorough","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit University of Wisconsin  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Clements","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh W.","family":"Delbridge","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Sippel","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit University of Wisconsin  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Sywak","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herb","family":"Chen","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit University of Wisconsin  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan B.","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Endocrine Surgical Unit The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.18.2164"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90321-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0285"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21653"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480507100907"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0307-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0492"},{"key":"e_1_2_7_11_1","first-page":"988","article-title":"Predictive value for disease progression of serum thyroglobulin levels measured in the postoperative period and after (131)I ablation therapy in patients with differentiated thyroid cancer","volume":"45","author":"Toubeau M","year":"2004","journal-title":"J. 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