{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:09:01Z","timestamp":1697432941016},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>To better define the prognostic role of nodal disease, evaluation of metastatic lymph node ratio (MLR<\/jats:styled-content>) has been performed, and this method has recently gained prominence in various gastrointestinal cancers. The present study attempts to identify prognostic factors and evaluate the independent prognostic influence of MLR<\/jats:styled-content> in patients who have undergone curative pancreaticoduodenectomy.<\/jats:p><\/jats:sec>Methods<\/jats:title>In our institution within the study period, 111 patients received curative pancreaticoduodenectomy for periampullary cancers. Clinicopathologic data were collected and MLR<\/jats:styled-content> was calculated for each of the patients. Patients were then divided into four groups based on MLR<\/jats:styled-content> value: MLR<\/jats:styled-content> 1 = 0; MLR<\/jats:styled-content> 2 = 0.01\u20130.2; MLR<\/jats:styled-content> 3 0.21\u20130.4; and MLR<\/jats:styled-content> 4 >0.4.<\/jats:p><\/jats:sec>Results<\/jats:title>Increasing MLR<\/jats:styled-content> correlates with high recurrence rate and lower overall survival (OS<\/jats:styled-content>) with significance (P<\/jats:italic> < 0.001, P<\/jats:italic> < 0.001). The recurrent group showed significantly lower OS<\/jats:styled-content> than the non\u2010recurrent group (P<\/jats:italic> < 0.001). In the multivariate analysis for recurrence, MLR<\/jats:styled-content> was identified as the only independent prognostic factor (P<\/jats:italic> < 0.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The simple and easily obtainable MLR<\/jats:styled-content> is well qualified as a prognostic factor in patients who undergo curatively radical resection for periampullary cancer. Furthermore, MLR<\/jats:styled-content> can overcome the limitations of evaluation of lymph nodes status, allowing it to be used as a potential prognostic factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12129","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T05:59:42Z","timestamp":1364018382000},"page":"353-358","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lymph node ratio predicts local recurrence for periampullary tumours"],"prefix":"10.1111","volume":"84","author":[{"given":"Sung Ryol","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Ook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Lai","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"23","article-title":"Significance of lymph node metastases in the surgical management of pancreatic head carcinoma","volume":"18","author":"Benassai G","year":"1999","journal-title":"J. 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