{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:50:50Z","timestamp":1792669850329,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T00:00:00Z","timestamp":1371600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients undergoing surgery for colorectal cancer are at high risk of post\u2010operative venous thromboembolism (<jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>). Thromboprophylaxis has been shown to have significant risk reduction, although there remains some controversy surrounding the optimal duration of pharmacological prophylaxis. Our institution does not routinely practise extended prophylaxis. The aim of this study was to retrospectively review the rate of post\u2010operative thromboprophylaxis in colorectal cancer patients, and incidence of symptomatic <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective audit of 200 consecutive patients who underwent colorectal surgery for cancer. Data to 90 days post\u2010operatively were collected from medical records and imaging and phone calls to patients and family practitioners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the patients, 98% received pharmacological prophylaxis, with a median duration of eight days. Eight (4%) symptomatic <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>s were diagnosed within the 90\u2010day follow\u2010up period: two deep vein thrombosis (<jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>s), five pulmonary emboli (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) and one patient with both <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>. A higher proportion of patients developed <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> if they received prophylaxis other than low molecular weight heparin and similarly there was a trend in increased risk of <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> in the presence of metastatic disease. However, using univariate analysis, these results were not statistically significant (<jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content> = 0.18 and 0.11, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The use of thromboprophylaxis was high in our centre, and the incidence of <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> was low when patients received a median of 8 days pharmacological prophylaxis combined with mechanical prophylaxis. The <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> incidence of 4% is similar to previous studies using extended prophylaxis. Our study findings do not support changing local protocol to extended prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12296","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T04:33:16Z","timestamp":1371702796000},"page":"284-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Venous thromboembolism prevention in patients undergoing colorectal surgery for cancer"],"prefix":"10.1111","volume":"84","author":[{"given":"Anna","family":"Holwell","sequence":"first","affiliation":[{"name":"General Internal Medicine Department St Vincent's Hospital  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2010Lyn","family":"McKenzie","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department St Vincent's Hospital  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Holmes","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department St Vincent's Hospital  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Woods","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department St Vincent's Hospital  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshal","family":"Nandurkar","sequence":"additional","affiliation":[{"name":"Haematology Department St Vincent's Hospital  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine S.","family":"Tam","sequence":"additional","affiliation":[{"name":"Haematology Department Peter MacCallum Cancer Institute  East Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazargan","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department St Vincent's Hospital  Fitzroy Victoria Australia"},{"name":"Haematology Department St Vincent's Hospital  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11458"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0108"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/828030"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.17.3078"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(02)00043-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009447"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/783214"},{"issue":"4","key":"e_1_2_6_9_1","article-title":"Heparins and mechanical methods for thromboprophylaxis in colorectal surgery","author":"Wille\u2010J\u00f8rgensen P","year":"2003","journal-title":"Cochrane Database Syst. 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