{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:27:47Z","timestamp":1772998067644,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Solid variant papillary thyroid cancer (<jats:styled-content style=\"fixed-case\">SVPTC<\/jats:styled-content>) is a rare type of thyroid malignancy whose clinical characteristics remain poorly defined. Therefore, we evaluated the characteristics of 14 patients with <jats:styled-content style=\"fixed-case\">SVPTC<\/jats:styled-content> treated at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of the 6052 patients with papillary thyroid cancer (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>) evaluated at our institution between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2008 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011, 14 (0.23%) had <jats:styled-content style=\"fixed-case\">SVPTC<\/jats:styled-content> and were analysed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 14 patients with <jats:styled-content style=\"fixed-case\">SVPTC<\/jats:styled-content>, two were men and 12 were women, with a mean age of 48.2 years (range: 33\u201372 years). The mean follow\u2010up period was 24 months (range: 8\u201336 months). All patients were assessed preoperatively by ultrasound\u2010guided fine needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>), with the diagnosis confirmed by permanent pathology and immunohistochemical staining performed by a specialized endocrine pathologist. Only one patient was diagnosed with <jats:styled-content style=\"fixed-case\">SVPTC<\/jats:styled-content> by preoperative <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>, whereas 11 (78.6%) were diagnosed with <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> or suspected of having <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>. The mean tumour size was 1.02 \u00b1 0.30\u2009cm, with all tumours less than 2.0\u2009cm in diameter. The infiltrative tumour margins were observed in eight patients (57.1%) and the extrathyroidal invasion in seven (50.0%). The central lymph node metastases were found in five patients (35.7%), and the lateral lymph node metastasis in one (7.1%). No patient experienced tumour recurrence or distant metastasis during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the small sample size and the short follow\u2010up period, our results indicate that <jats:styled-content style=\"fixed-case\">SVPTC<\/jats:styled-content> may not be as aggressive a subtype as previously thought.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12307","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T11:58:38Z","timestamp":1372939118000},"page":"380-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clinicopathologic features of solid variant papillary thyroid cancer"],"prefix":"10.1111","volume":"84","author":[{"given":"Hojin","family":"Chang","sequence":"first","affiliation":[{"name":"Thyroid Cancer Center Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Center Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Won","family":"Chun","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Center Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bup Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Center Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Sang","family":"Lee","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Center Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang\u2010Seok","family":"Chang","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Center Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Won","family":"Hong","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Center Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Pathology Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheong Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Center Gangnam Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine  Seoul 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