{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:48:04Z","timestamp":1764510484921},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Gastrointestinal stromal tumours (GIST<\/jats:styled-content>s) are the most common mesenchymal tumours of the gastrointestinal tract and make up 1\u20132% of all gastrointestinal malignancies. Traditionally, the treatment of choice for primary disease is surgical resection; however, no single surgeon or institution gets extensive exposure to these patients so appropriate decision\u2010making is difficult, particularly since the introduction of the tyrosine kinase inhibitor imatinib, which has become an important additional management tool.<\/jats:p><\/jats:sec>Method<\/jats:title>All patients were diagnosed and treated for GIST<\/jats:styled-content>s in C<\/jats:styled-content>hristchurch H<\/jats:styled-content>ospital (C<\/jats:styled-content>hristchurch, N<\/jats:styled-content>ew Z<\/jats:styled-content>ealand) between 1 J<\/jats:styled-content>anuary 2000 and 31 D<\/jats:styled-content>ecember 2010. We maintain a prospective database of all patients with GIST<\/jats:styled-content>s. Data on clinical and histopathological variables, management and survival outcomes were recorded. These were then reviewed.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 93 patients in this study. Fifty were women. Median age was 69 (interquartile range (IQR<\/jats:styled-content>) 59\u201376) years. Fifty\u2010one tumours were located in the stomach, 27 in the small bowel, six in the colon, three in the oesophagus, one in the rectum and five were extra\u2010gastrointestinal. In total, 22 patients received imatinib therapy; four patients with metastatic disease had imatinib as sole therapy. The median follow\u2010up was 58 (IQR<\/jats:styled-content> 30\u201390) months. The 5\u2010year overall survival and disease\u2010free survival (DFS<\/jats:styled-content>) for the entire study population was 69% and 64%, respectively. The 5\u2010year DFS<\/jats:styled-content> was higher for all patients who have localized disease when compared with those who have metastatic disease (76% versus 28%, P<\/jats:italic>\u2010value 0.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Surgery aiming at an R<\/jats:styled-content>0 resection remains the mainstay of treatment. We propose the most effective way to grow the knowledge base in N<\/jats:styled-content>ew Z<\/jats:styled-content>ealand is the establishment of a national register, thereby allowing better clinical decision\u2010making by interpretation of a larger data set.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12429","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T10:28:41Z","timestamp":1386757721000},"page":"162-166","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ten\u2010year review of gastrointestinal stromal tumours at a tertiary referral hospital in N<\/scp>ew Z<\/scp>ealand"],"prefix":"10.1111","volume":"86","author":[{"given":"Joey","family":"Siu","sequence":"first","affiliation":[{"name":"Colorectal Unit, Department of Surgery Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lim","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of Surgery Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Fischer","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of Surgery Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Dobbs","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of Surgery Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Wakeman","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of Surgery Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Ing","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of Surgery Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Frizelle","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of Surgery Christchurch Hospital Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2011.06.007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0116"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21460"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200001000-00008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.2980100508"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020461"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21890"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02291.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.5858\/2008-0083-RSR2.1","article-title":"Gastrointestinal stromal tumors: a review of the literature","volume":"134","author":"Laurini JA","year":"2010","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020701716490"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1496-z"},{"issue":"4","key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"iv64","DOI":"10.1093\/annonc\/mdp131","article-title":"Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow\u2010up","volume":"20","author":"Casali PG","year":"2009","journal-title":"Ann. Oncol."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23199"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2006.09.004"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11374"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.4403"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21892"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000218080.94145.cf"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2012.05.007"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60500-6"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60680-0"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.12429","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.12429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:57:05Z","timestamp":1695477425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.12429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,11]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/ans.12429"],"URL":"https:\/\/doi.org\/10.1111\/ans.12429","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,11]]},"assertion":[{"value":"2013-04-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}