{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:10:57Z","timestamp":1696399857420},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Injection of local anaesthetic agents around the prostatic nerve bundles during transrectal ultrasonography (TRUS<\/jats:styled-content>) biopsy of the prostate has shown to reduce the pain associated with the procedure. It has been shown that some of the discomfort associated with the procedure is secondary to spasm of the anal sphincter. Topical diltiazem can relax the anal sphincter. Our aim was to evaluate the use of topical diltiazem cream as an adjunct to periprostatic nerve block in reducing pain associated with TRUS<\/jats:styled-content>\u2010guided prostatic biopsy.<\/jats:p><\/jats:sec>Method<\/jats:title>Between S<\/jats:styled-content>eptember 2009 and S<\/jats:styled-content>eptember 2010, 114 patients were enrolled in the trial (from two centres). Patients undergoing TRUS<\/jats:styled-content> biopsy of prostate were randomized into diltiazem and placebo groups. Patients were asked to fill out a questionnaire at the end of the procedure. The questionnaire enquired about discomfort associated with various parts of the procedure using a 10\u2010cm visual analogue scale (VAS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>For discomfort due to the presence of the probe, pain during the biopsy and overall pain prior to leaving the department, mean VAS<\/jats:styled-content> was higher for the placebo group, but the difference was not statistically significant.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Diltiazem cream has a better side effect profile than glyceryl trinitrate cream and is better tolerated. Although we have demonstrated trends favouring diltiazem use as an adjunct to local anaesthetic in TRUS<\/jats:styled-content> biopsy of the prostate, this did not reach a statistically significant level. The pain scores associated with TRUS<\/jats:styled-content> biopsy in our cohort were lower than those in the published literature. This phenomenon might have contributed to the results observed in this trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12438","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T12:20:09Z","timestamp":1384777209000},"page":"430-432","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical diltiazem before transrectal ultrasonography\u2010guided biopsy of the prostate: a randomized controlled trial"],"prefix":"10.1111","volume":"85","author":[{"given":"Homayoun","family":"Zargar","sequence":"first","affiliation":[{"name":"Urology Midcentral Health Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Marshall","sequence":"additional","affiliation":[{"name":"Urology Waikato Hospital Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesh","family":"Siva","sequence":"additional","affiliation":[{"name":"Statistics AgResearch Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quinten","family":"King","sequence":"additional","affiliation":[{"name":"Urology Midcentral Health Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000181212.51025.06"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.06990.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000149872.35473.cb"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.00440.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0135-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.09.065"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03042.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-003-0079-5"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.12438","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.12438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:34:40Z","timestamp":1696361680000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.12438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,18]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/ans.12438"],"URL":"https:\/\/doi.org\/10.1111\/ans.12438","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,18]]},"assertion":[{"value":"2013-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}