{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:42Z","timestamp":1787755482153,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent literature has suggested an association between autoimmune thyroiditis and papillary thyroid cancer. The aims of this study were to evaluate if positive thyroid antibodies are associated with thyroid carcinoma and to examine the role of thyroid antibodies in the management of thyroid nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a database study of all patients undergoing thyroidectomy with recorded preoperative thyroid antibodies (autoantibodies to thyroglobulin and\/or thyroid peroxidase) levels from 2010 to 2012. We analysed preoperative thyroid antibody levels, fine needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>) results, type of thyroid surgery and final histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 960 patients who underwent thyroidectomy with recorded preoperative thyroid antibodies. Of 960 patients, 784 had preoperative <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> of thyroid nodules. Final histopathology showed 758 benign and 202 malignant cases. As expected, there was a strong association between raised thyroid antibodies and lymphocytic thyroiditis on histology (<jats:italic>P<\/jats:italic> = 0.0001) (two\u2010sided probability). Overall, positive thyroid antibodies were not found to be a predictor of thyroid carcinoma (<jats:italic>P<\/jats:italic> = 0.161) (two\u2010sided probability). However, in patients with benign <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>, positive thyroid antibodies increased the risk of thyroid malignancy (odds ratio 2.16; 95% confidence interval 1.11 to 4.21, <jats:italic>P<\/jats:italic> = 0.027) (two\u2010sided probability).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with positive thyroid antibodies have a greater risk of malignancy in those with benign <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>. We recommend routine thyroid antibody assessment in addition to <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> as part of the assessment of thyroid nodules.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12453","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T07:45:51Z","timestamp":1386056751000},"page":"849-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010thyroid antibodies as a predictor of thyroid cancer"],"prefix":"10.1111","volume":"85","author":[{"given":"Sze Ling","family":"Wong","sequence":"first","affiliation":[{"name":"Endocrine Surgery Unit Monash University Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Grodski","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit Monash University Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meei J.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit Monash University Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Serpell","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit Monash University Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2008.01.003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.10.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1046"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.12.037"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0035"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2011.05707.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0450"},{"key":"e_1_2_6_11_1","first-page":"9","article-title":"2009 Coexistence of papillary carcinoma and Hashimoto's thyroiditis","volume":"48","author":"Matesa\u2010Anic D","year":"2009","journal-title":"Acta Clin. 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