{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:33:22Z","timestamp":1776425602651,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A number of interventions have been used to decrease the incidence of post\u2010operative paralytic ileus. A secondary outcome of a randomized controlled study showed that <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">2<\/jats:styled-content> inhibitors decreased the incidence of paralytic ileus. We sought to study a large cohort of patients undergoing major abdominal operations who were treated with a <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">2<\/jats:styled-content> inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective review of prospectively collected data. All eligible patients were given a <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">2<\/jats:styled-content> inhibitor \u2013 celecoxib 100\u2009mg \u2013 twice daily starting on the day of surgery until the seventh day post\u2010operatively or discharge, whichever was earlier. The rate of paralytic ileus was calculated and compared with historical data. Secondary outcome measures were the effect of using <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">2<\/jats:styled-content> inhibitors on renal function, electrolytes and haemoglobin, morbidity and leak rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and fifty\u2010two patients were treated with celecoxib; the control arm consisted of 67 historical patients. Of the 252 patients, we had complete data for 235 patients and ileus in 17 patients (7.23%) compared with 13.4% in the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.05). Subgroup analysis showed ileus in 5.45% of colectomy patients and 6.36% of patients who have had a colectomy and high anterior resection. There was no detriment of measured blood tests. There were leaks in two treated patients, both of whom did not require a laparotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of low\u2010dose <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">2<\/jats:styled-content> inhibitor over a short period of time decreases the paralytic ileus rates and does not cause any significant morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12475","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T06:51:28Z","timestamp":1385448688000},"page":"946-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and safety of low\u2010dose celecoxib in reducing post\u2010operative paralytic ileus after major abdominal surgery"],"prefix":"10.1111","volume":"85","author":[{"given":"Devinder P.","family":"Raju","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Flinders Medical Center  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hakendorf","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Flinders Medical Center  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Human Physiology Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Wattchow","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Flinders Medical Center Flinders Private Hospital Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000232538.72458.93"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00602.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-3150.2004.00558.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.01.041"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29605"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04126.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070428"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31818b7595"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181fcb83e"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.00965.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08711-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60357-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9386-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09290-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-009-0652-7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/01.sla.0000141158.27977.66","article-title":"Alvimopan, a novel, peripherally acting mu opioid antagonist results of a multicenter, randomized, double\u2010blind, placebo\u2010controlled, phase III trial of major abdominal surgery and postoperative ileus","volume":"240","author":"Wolff BG","year":"2004","journal-title":"Ann. 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