{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T18:30:14Z","timestamp":1786473014571,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early oral feeding (<jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content>) following colorectal surgery can accelerate patient recovery and shorten hospital stay. However, some patients are intolerable to postoperative early oral feeding. The aim of this study was to evaluate the tolerability of <jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content> following laparoscopic colorectal cancer surgery and the effects of intravenous lidocaine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort in this randomized, placebo\u2010controlled trial (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linical<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rial.gov, <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01346917) comprised of 77 patients undergoing elective laparoscopic colorectal cancer surgery. For patients randomized to the lidocaine group, a loading dose of 1\u2009mg\/kg lidocaine prior to skin incision, and a continuous dose of 1\u2009mg\/kg\/h lidocaine with 90\u2009mg ketorolac (non\u2010steroidal anti\u2010inflammatory drug) (in normal saline, total 240\u2009mL) was administered for 24\u2009h. Patients randomized to the placebo group received a loading dose of 5\u2009mL saline and a continuous dose of 90\u2009mg ketorolac in 240\u2009mL saline. The primary outcome measure was prevalence of postoperative nausea\/vomiting and intolerance to <jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 68 patients completed the study and were analyzed. Postoperative nausea and vomiting were higher in the control group but did not reach statistical significance (<jats:italic>P<\/jats:italic> = 0.054). Tolerability of <jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content> was 96.9% in the lidocaine group and 91.7% in the control group (<jats:italic>P<\/jats:italic> = 0.62). There was no difference in postoperative pain, opioid consumption, bowel function recovery or postoperative hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Perioperative intravenous lidocaine administered for laparoscopic colorectal cancer surgery might reduce postoperative nausea and vomiting. However, a high tolerability to <jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content> following colorectal surgery can be achieved by laparoscopic surgery alone without other supportive treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12550","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:08:10Z","timestamp":1393265290000},"page":"539-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Early oral feeding following laparoscopic colorectal cancer surgery"],"prefix":"10.1111","volume":"84","author":[{"given":"Hyung Ook","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ryol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Joon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hungdai","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181fcdb3e"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2009.03.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-010-1089-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1177\/000313481207801030","article-title":"A prospective single\u2010institution evaluation of current practices of early postoperative feeding after elective intestinal surgery","volume":"78","author":"Rohatiner T","year":"2012","journal-title":"Am. 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