{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:12:24Z","timestamp":1788318744058,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T00:00:00Z","timestamp":1407801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Perineural invasion (\n PNI<\/jats:styled-content>\n ) may influence the prognosis of colon cancer, but little is known about its predictive value. The aim of this study was to reveal the role of\n PNI<\/jats:styled-content>\n in predicting prognosis after curative resection of colon cancer, especially\n T3N0<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Two hundred and fifty\u2010five patients who underwent curative resection for colon cancer at\n S<\/jats:styled-content>\n amsung\n M<\/jats:styled-content>\n edical\n C<\/jats:styled-content>\n enter and were later diagnosed with stage\n T3N0<\/jats:styled-content>\n by a pathological report between\n N<\/jats:styled-content>\n ovember 2004 and\n D<\/jats:styled-content>\n ecember 2007 were retrospectively recruited into the study.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among the 255 patients, 156 were male and 99 were female. The mean age was 61 years (range, 25 to 88 years). The most common tumour location was the sigmoid colon (93 patients, 36.5%). The median follow\u2010up period was 61 months (range, 1 to 98 months).\n PNI<\/jats:styled-content>\n was detected in 18 patients (7.1%). Adjuvant chemotherapy was performed in 205 patients (80.4%). The 5\u2010year disease\u2010free survival rate was greater for patients with\n PNI<\/jats:styled-content>\n negative tumours compared with those with\n PNI<\/jats:styled-content>\n positive tumours (92.0% versus 76.0%,\n P<\/jats:italic>\n = 0.025). Adjuvant chemotherapy was not associated with significant differences in survival rate (94.8% versus 96.9%,\n P<\/jats:italic>\n = 0.625). On multivariate analysis,\n PNI<\/jats:styled-content>\n was an independent prognostic factor for disease\u2010free and overall survival (\n P<\/jats:italic>\n = 0.046, hazard ratio (HR) = 3.113, 95% confidence interval (\n CI<\/jats:styled-content>\n ) = 1.020\u20139.505 and\n P<\/jats:italic>\n = 0.019,\n HR<\/jats:styled-content>\n = 9.395, 95%\n CI<\/jats:styled-content>\n = 1.453\u201360.755 respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n PNI<\/jats:styled-content>\n is the only significant prognostic factor affecting disease\u2010free and overall survival in patients with\n T3N0<\/jats:styled-content>\n colon cancer.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ans.12810","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T05:54:06Z","timestamp":1407822846000},"page":"1007-1013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic significance of perineural invasion in stage\n IIA<\/scp>\n colon cancer"],"prefix":"10.1111","volume":"86","author":[{"given":"Jung\u2010A","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok\u2010Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Beom","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hyeon","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Kyung","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2012.44.1.11"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh275"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960815)78:4<918::AID-CNCR32>3.0.CO;2-W"},{"key":"e_1_2_6_6_1","unstructured":"National Comprehensive Cancer Network.Rectal Cancer. 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