{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:48:14Z","timestamp":1792601294718,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T00:00:00Z","timestamp":1409616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pathological fractures are a significant and often devastating event in the progression of metastatic bone disease. They are frequently a marker of end\u2010stage cancer and the end of functional independence. Although several studies look into prognosis following the development of metastatic lesions, few look into the prognosis after the fracture itself. This study investigates the variables affecting prognosis in patients suffering pathological fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective clinical audit of 72 patients from the <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>rthopaedic <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nit at <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>remantle <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital in <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia. The variables of interest include primary cancer, fracture site, method of fixation, use of cement augmentation, appendicular metastatic load, spinal metastatic load, presence of visceral metastases, patient co\u2010morbidities and functional scoring before and after the fracture has occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median time between diagnosis of cancer to pathological fracture was 8.3 months, while the median survival post\u2010fracture was 3.3 months. There is a statistically significant correlation between patient survival and primary cancer type, spinal metastatic burden and functional performance score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, the prognosis following pathological fracture is extremely poor. We propose that these variables are scrutinized by the treating orthopaedic team preoperatively to help guide management and provide patients and their families with a realistic expectation of functional outcome and survival time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12830","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T02:37:45Z","timestamp":1409711865000},"page":"159-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prognostic factors following pathological fractures"],"prefix":"10.1111","volume":"85","author":[{"given":"Thomas","family":"Hill","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Fremantle Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"D'Alessandro","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Fremantle Hospital  Perth Western Australia Australia"},{"name":"School of Surgery The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Murray","sequence":"additional","affiliation":[{"name":"Centre for Applied Statistics The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piers","family":"Yates","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Fremantle Hospital  Perth Western Australia Australia"},{"name":"School of Surgery The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8 <1588::AID-CNCR9>3.0.CO;2-G"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.84B4.12495"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679508995508"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.104"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2013.788437"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-2038-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.09.018"},{"key":"e_1_2_5_9_1","first-page":"128","article-title":"Failures after operation for skeletal metastatic lesions of long bones","author":"Wedin R","year":"1999","journal-title":"Clin. 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