{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:11:39Z","timestamp":1772842299357,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study sought to determine the number of hospital admissions for sepsis following transrectal ultrasound\u2010guided (<jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content>) biopsy, and the rate of both prophylactic and therapeutic use of carbapenem antibiotics for <jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content> biopsy, at a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of prospectively collected data from the medical records electronic database of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>abrini <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth, a private metropolitan hospital, was queried for coding of admissions under any admitting urologist for sepsis and prostate\u2010related infections from 2009 to 2012. Records were examined for whether a <jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content> biopsy had been performed within 14 days prior and if a therapeutic carbapenem was required. The database also queried the use of carbapenems as prophylaxis in patients undergoing <jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content> biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 63 admissions for <jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content> biopsy sepsis, multi\u2010drug\u2010resistant organisms were isolated from 26 (41%). Twenty\u2010three admissions were from the 1937 patients who underwent a <jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content> biopsy at <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>abrini (a sepsis rate of 1.2%) and 40 were following <jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content> biopsies at other centres. Thirty\u2010seven (58.7%) patients received therapeutic carbapenems either empirically, or after culture results. Of the 1937 <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>abrini <jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content> biopsy patients, 154 (8%) were given a carbapenem as prophylaxis, with a rapid increase in prophylactic use over the 4 years studied from 0.25% to 13%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study did not show evidence of an increasing rate of hospital admissions for <jats:styled-content style=\"fixed-case\">TRUS<\/jats:styled-content> biopsy sepsis at this institution. However, there was a dramatic uptake in prophylactic administration of carbapenems. Increasing carbapenem use may contribute to development of carbapenem\u2010resistant bacteria. Alternative methods of prostate biopsy that avoid sepsis should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12933","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T08:07:17Z","timestamp":1419926837000},"page":"931-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transrectal ultrasound\u2010guided biopsy sepsis and the rise in carbapenem antibiotic use"],"prefix":"10.1111","volume":"85","author":[{"given":"Olivia R.","family":"Leahy","sequence":"first","affiliation":[{"name":"Alfred Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"Cabrini Health  Melbourne Victoria Australia"},{"name":"Eastern Health  Melbourne Victoria Australia"},{"name":"Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Dyer","sequence":"additional","affiliation":[{"name":"Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Phillips","sequence":"additional","affiliation":[{"name":"Cabrini Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy P.","family":"Grummet","sequence":"additional","affiliation":[{"name":"Alfred Health  Melbourne Victoria Australia"},{"name":"Cabrini Health  Melbourne Victoria Australia"},{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Epworth Healthcare  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.06.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.056"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.06.057"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10621.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.12.058"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10561.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03638.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.11.088"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis194"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006576.pub2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/653932"},{"key":"e_1_2_7_14_1","unstructured":"Australian Commission on Safety and Quality in Health Care.Recommendations for the control of multi\u2010drug resistant gram\u2010negatives: carbapenem resistant Enterobacteriaceae (October 2013). 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