{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:01:21Z","timestamp":1790884881012,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The objective of this study was to compare pain intensity in patients undergoing transrectal ultrasound (TRUS<\/jats:styled-content>)\u2010guided biopsy of the prostate with P<\/jats:styled-content>enthrox alone compared with P<\/jats:styled-content>enthrox plus periprostatic infiltration of local analgesia (PILA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Method<\/jats:title>Seventy\u2010two subjects participated in this study after receiving appropriate education. Forty\u2010two patients self\u2010administered inhaled P<\/jats:styled-content>enthrox (3\u2009mL methoxyflurane) alone for analgesia (G<\/jats:styled-content>roup A<\/jats:styled-content>), followed by 30 patients who self\u2010administered P<\/jats:styled-content>enthrox and received PILA<\/jats:styled-content> with 5\u2009mL of 2% lignocaine. All subjects had TRUS<\/jats:styled-content> biopsy performed. Immediately after the procedure, patients were asked to rate their pain intensity using a numerical verbal rating scale from 0 to 10.<\/jats:p><\/jats:sec>Results<\/jats:title>Baseline characteristics of the two groups were similar. Patients in G<\/jats:styled-content>roup B<\/jats:styled-content> reported significantly lower post TRUS<\/jats:styled-content> biopsy median pain intensity of 2 (1\u20133) compared with G<\/jats:styled-content>roup A<\/jats:styled-content> subjects who reported a median post TRUS<\/jats:styled-content> biopsy pain intensity of 3 (2\u20135) (P<\/jats:italic> = 0.014). A total of 72 men underwent TRUS<\/jats:styled-content>\u2010guided biopsy. All patients indicated they would be happy to have another TRUS<\/jats:styled-content>\u2010guided prostate biopsy in the future.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study shows that P<\/jats:styled-content>enthrox plus PILA<\/jats:styled-content> shows promise as an efficacious and easily tolerated analgesic technique for outpatient TRUS<\/jats:styled-content> biopsy, keeping resource use to a minimum. Planning for a multi\u2010centre, double\u2010blind randomized control trial comparing P<\/jats:styled-content>enthrox plus PILA<\/jats:styled-content> with PILA<\/jats:styled-content> alone is presently underway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.12974","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T02:19:25Z","timestamp":1423189165000},"page":"139-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Penthrox alone versus Penthrox plus periprostatic infiltration of local analgesia for analgesia in transrectal ultrasound\u2010guided prostate biopsy"],"prefix":"10.1111","volume":"86","author":[{"given":"Sean","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Urology Bairnsdale Regional Health Service Bairnsdale Victoria Australia"},{"name":"Department of Urology Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Pepdjonovic","sequence":"additional","affiliation":[{"name":"Department of Urology Bairnsdale Regional Health Service Bairnsdale Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Konstantatos","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Anaesthesia and Perioperative Medicine Alfred Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Frydenberg","sequence":"additional","affiliation":[{"name":"Department of Urology Bairnsdale Regional Health Service Bairnsdale Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria Australia"},{"name":"Department of Urology Monash Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Grummet","sequence":"additional","affiliation":[{"name":"Department of Urology Bairnsdale Regional Health Service Bairnsdale Victoria Australia"},{"name":"Department of Urology Alfred Health Melbourne Victoria Australia"},{"name":"Department of Surgery Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000181212.51025.06"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12433"},{"key":"e_1_2_5_4_1","unstructured":"Medical Developments International Ltd.PENTHROX (methoxyflurane) Inhalation: Product Information.2014. 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