{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:14:30Z","timestamp":1758122070586},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,2,23]],"date-time":"2015-02-23T00:00:00Z","timestamp":1424649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Over the last decade, there has been a shift towards endoscopic treatment of high\u2010grade dysplasia (<jats:styled-content style=\"fixed-case\">HGD<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1 stage adenocarcinoma arising in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arrett's oesophagus. Although short\u2010term outcomes are promising, longer\u2010term outcomes remain uncertain and the role of these therapies versus surgery is debated, with surgical mortality rates assumed. However, few studies have specifically determined the outcome for oesophagectomy in the subgroup with <jats:styled-content style=\"fixed-case\">HGD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1 adenocarcinoma. To determine this, we evaluated experience with oesophagectomy for <jats:styled-content style=\"fixed-case\">HGD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1 adenocarcinoma in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arrett's oesophagus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were analysed from a prospective audit database for oesophagectomy performed at two public and four associated private hospitals in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>delaide, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>outh <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia. Patients with <jats:styled-content style=\"fixed-case\">HGD<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1a and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1b adenocarcinoma who underwent oesophagectomy from 20\u2009<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 1998 to 17\u2009<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2012 were identified, and their perioperative, post\u2010operative and survival outcomes were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 452 oesophagectomy procedures, 63 (13.9%) individuals who underwent surgery for <jats:styled-content style=\"fixed-case\">HGD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1 adenocarcinoma were identified; <jats:styled-content style=\"fixed-case\">HGD<\/jats:styled-content> \u2013 19 (30.1%), <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1a \u2013 18 (28.5 %), <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1b \u2013 26 (41.3%). Major complications occurred in eight (12.7%) patients including one (1.6%) death following surgery. Five\u2010year survival for <jats:styled-content style=\"fixed-case\">HGD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1a cancers using <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier analysis was not significantly different from a matched general population without cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oesophagectomy for <jats:styled-content style=\"fixed-case\">HGD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1 stage adenocarcinoma in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arrett's oesophagus is associated with favourable outcomes. Outcomes following endoscopic treatments should be benchmarked against these outcomes, not those following oesophagectomy for advanced cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13023","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T03:42:01Z","timestamp":1424749321000},"page":"905-909","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oesophagectomy is a safe option for early adenocarcinoma arising from <scp>B<\/scp>arrett's oesophagus"],"prefix":"10.1111","volume":"86","author":[{"given":"Yick Ho","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Surgery Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Bright","sequence":"additional","affiliation":[{"name":"Department of Surgery Flinders University  Adelaide South Australia 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