{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:52:00Z","timestamp":1761519120366},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Anaplastic large\u2010cell lymphoma (ALCL<\/jats:styled-content>) has recently been reported in women with breast implants. The incidence of breast implant\u2010related ALCL<\/jats:styled-content> is extremely rare and most surgeons would not expect to see this disease in their career. However, the senior author has had three women present to his practice with ALCL<\/jats:styled-content> over a 2\u2010year period.<\/jats:p><\/jats:sec>Methods<\/jats:title>The three patients and their presentation were reviewed to establish the presenting complaint in each case of subsequently diagnosed ALCL<\/jats:styled-content>. Literature was reviewed to establish appropriate treatment protocols for any subsequent patients.<\/jats:p><\/jats:sec>Results<\/jats:title>The average time between first implant placement and presentation with breast implant\u2010associated ALCL<\/jats:styled-content> was 13.3 years (range: 10\u201316 years) and age at presentation was 49 years (range: 45\u201353 years). Each presentation was somewhat different, being a palpable mass, a painless seroma and a painful seroma. Both patients with seroma underwent ultrasound\u2010guided aspiration of fluid which confirmed ALCL<\/jats:styled-content>. All patients underwent implant removal and complete capsulectomy. The patient with a mass at presentation initially declined adjuvant treatment but subsequently developed an ALCL<\/jats:styled-content>\u2010associated seroma and was treated with surgery and post\u2010operative chemotherapy.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Patients with breast implant\u2010associated ALCL<\/jats:styled-content> can present with different clinical signs and symptoms. Late seroma is a relatively common presentation of breast implant\u2010associated ALCL<\/jats:styled-content>. While firm guidelines for the management of breast implant\u2010related ALCL<\/jats:styled-content> are lacking, we suggest that any late seroma in the absence of infection should be managed with aspiration and cytological analysis of the fluid.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13074","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T20:54:51Z","timestamp":1428008091000},"page":"789-794","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Variable presentation of anaplastic large\u2010cell lymphoma in patients with breast implants"],"prefix":"10.1111","volume":"87","author":[{"given":"Michelle B.","family":"Locke","sequence":"first","affiliation":[{"name":"Department of Surgery South Auckland Clinical Campus Middlemore Hospital University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Lofts","sequence":"additional","affiliation":[{"name":"Private Practice Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91328-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199708000-00065"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318221db81"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/PAI.0b013e318266476c","article-title":"Anaplastic large cell lymphoma occurring in association with breast implants: review of pathologic and immunohistochemical features in 103 cases","volume":"21","author":"Taylor CR","year":"2013","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X11407872"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31827faff2"},{"key":"e_1_2_5_8_1","unstructured":"Center for Devices and Radiological Health USFaDA.Anaplastic Large Cell Lymphoma (ALCL) in Women with Breast Implants: Preliminary FDA Findings and Analysis. [Cited 13 Apr 2014.] Available from URL:http:\/\/www.fda.gov\/MedicalDevices\/ProductsandMedicalProcedures\/ImplantsandProsthetics\/BreastImplants\/ucm239996.htm"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10163"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182450aae"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2780"},{"key":"e_1_2_5_12_1","unstructured":"SocietyACWhat are the Risk Factors for Non\u2010Hodgkin Lymphoma? Georgia USA. [updated 2015; Cited 5 Jan 2015.] Available from URL:http:\/\/www.cancer.org\/cancer\/non\u2010hodgkinlymphoma\/detailedguide\/non\u2010hodgkin\u2010lymphoma\u2010risk\u2010factors"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.008250"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0068-RS"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23152"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1331"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.585"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182172418"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318221db96"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.7911"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.2778"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31821f9f23"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31824a9e6d"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318217fdb0"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355861"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.13074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:17:41Z","timestamp":1695554261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.13074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/ans.13074"],"URL":"https:\/\/doi.org\/10.1111\/ans.13074","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"2015-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}