{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:30:13Z","timestamp":1781749813859,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Acute appendicitis (AA<\/jats:styled-content>) is a common indication for urgent abdominal surgery. CA<\/jats:styled-content>\u2010125 glycoprotein antigen is a non\u2010specific marker for epithelial ovarian cancer; CA<\/jats:styled-content>\u2010125 serum levels also increased in the conditions of peritoneal inflammation. The aim of this study was to examine the correlation between serum CA<\/jats:styled-content>\u2010125 levels and AA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>All emergency department (ED<\/jats:styled-content>) patients with suspected AA<\/jats:styled-content> were prospectively enrolled in the study. The serum level of CA<\/jats:styled-content>\u2010125 was checked in every patient on arrival to the ED<\/jats:styled-content> in addition to the routine clinical and laboratory evaluation. Data regarding demographic, clinical, radiological, operative and pathological features were analysed.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred consecutive patients (48 males) were enrolled in the study. We found a statistically significant correlation between CA<\/jats:styled-content>\u2010125 levels in males and the severity of appendicitis as described in the operative and pathology reports (P<\/jats:italic> = 0.008 and P<\/jats:italic> = 0.02, respectively). In addition, we observed a trend towards higher levels of CA<\/jats:styled-content>\u2010125 in males with AA<\/jats:styled-content> compared with males without AA<\/jats:styled-content> (9.9 \u00b1 4.7 versus 7.8 \u00b1 3.2\u2009U<\/jats:styled-content>\/mL, respectively; P<\/jats:italic> = 0.09).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CA<\/jats:styled-content>\u2010125 levels correlate with the severity of appendicitis in males and may serve as a surrogate marker for the severity of other intra\u2010abdominal surgical diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13128","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T09:43:01Z","timestamp":1431423781000},"page":"260-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Elevations of serum CA<\/scp>\u2010125 predict severity of acute appendicitis in males"],"prefix":"10.1111","volume":"86","author":[{"given":"Yaniv","family":"Berger","sequence":"first","affiliation":[{"name":"Department of Surgery and Transplantation Chaim Sheba Medical Center Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinoam","family":"Nevler","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2012 Chaim Sheba Medical Center Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaya","family":"Shwaartz","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation Chaim Sheba Medical Center Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylon","family":"Lahat","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation 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