{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:43:17Z","timestamp":1696394597164},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reamed intramedullary nailing is the gold standard for management of femur fractures. Nailing within 24\u2009h is proven to reduce complications from ongoing bleeding, soft\u2010tissue damage and pain. However, when combined with haemorrhagic shock, femur fracture and intramedullary nailing are associated with immune\u2010mediated damage to remote organs. We studied whether delaying fracture fixation until resuscitation was succeeding would lead to a significant reduction in remote organ damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty male rabbits underwent closed femur fracture, haemorrhagic shock, resuscitation and either immediate nailing (group: ImmFix, <jats:italic>n<\/jats:italic> = 9), delayed nailing (group: DelFix, <jats:italic>n<\/jats:italic> = 8) or just splinting (group: NoFix, <jats:italic>n<\/jats:italic> = 3). Haemorrhagic shock was maintained for 60\u2009min. Resuscitation was with shed blood and <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>artmann's solution. Animals were euthanized 8\u2009h after fixation; the lungs and small bowel were scored histologically by two pathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Groups did not differ in weight, haemorrhage volume or magnitude of shock. At 8\u2009h, there was no difference in end\u2010organ damage between <jats:styled-content style=\"fixed-case\">ImmFix<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DelFix<\/jats:styled-content> groups (11.3 \u00b1 1.6 and 13.2 \u00b1 1.6 versus 8.1 \u00b1 1.3 and 12.9 \u00b1 1.1, <jats:italic>P<\/jats:italic> = 0.26 between groups). However, the <jats:styled-content style=\"fixed-case\">NoFix<\/jats:styled-content> group had significantly greater end\u2010organ damage when compared with the fixation at any time groups (17.3 \u00b1 2.7 and 17.0 \u00b1 3.3 versus 9.8 \u00b1 1.1 and 13.1 \u00b1 1, <jats:italic>P<\/jats:italic> = 0.01 between groups).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this laboratory model, we have demonstrated that timely femur fracture fixation outweighs the potential harmful effects of surgery performed during haemorrhagic shock with simultaneous resuscitation. We have failed to demonstrate a difference between immediate and delayed fixation during resuscitation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13197","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T09:32:49Z","timestamp":1434447169000},"page":"966-971","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of the timing of internal fixation of femur fractures during shock resuscitation on remote organ damage"],"prefix":"10.1111","volume":"85","author":[{"given":"Benjamin M.","family":"Hardy","sequence":"first","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle  Newcastle New South Wales Australia"},{"name":"Department of Traumatology John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yoshino","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle  Newcastle New South Wales Australia"},{"name":"Department of Traumatology John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony W.","family":"Quail","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle  Newcastle New South Wales Australia"},{"name":"Department of Anaesthesia and Intensive Care John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt J.","family":"Balogh","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle  Newcastle New South Wales Australia"},{"name":"Department of Traumatology John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2004.07.031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198971030-00004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60991-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.02.011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B6.17359"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181485750"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181b890be"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2010.05582.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200209000-00010"},{"key":"e_1_2_7_11_1","first-page":"H1120","article-title":"Cardiac and arterial baroreceptor influences in release of vasopressin and renin during hemorrhage","volume":"252","author":"Quail AW","year":"1987","journal-title":"Am. 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