{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:44:46Z","timestamp":1789447486201,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Treatment of peritoneal metastases (PM<\/jats:styled-content>) and liver metastases (LM<\/jats:styled-content>) from colon cancer remains controversial. LM<\/jats:styled-content> has been viewed as exclusion criterion for cytoreductive surgery (CRS<\/jats:styled-content>) on the basis that such spread represents systemic disease. CRS<\/jats:styled-content> and intraperitoneal chemotherapy (IPC<\/jats:styled-content>) has gained increasing recognition as a treatment modality for selected patients with colon cancer and PM<\/jats:styled-content>. This study analyses results of CRS<\/jats:styled-content> and IPC<\/jats:styled-content> for colon cancer and synchronous resection for treatment of LM<\/jats:styled-content> and PM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010eight patients with PM<\/jats:styled-content>\/LM<\/jats:styled-content> colon cancer were analysed. Forty\u2010two patients with PM<\/jats:styled-content> were treated for disease limited to the peritoneum (A), and 36 patients received treatment for both PM<\/jats:styled-content> and LM<\/jats:styled-content> (B). Overall survival (OS<\/jats:styled-content>), disease\u2010free survival (DFS<\/jats:styled-content>), morbidity, mortality and recurrence were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>Median OS<\/jats:styled-content> and DFS<\/jats:styled-content> was 32.8 and 13.5 months. The median OS<\/jats:styled-content> for A and B were 45.5 and 24.4 months respectively. Within B patients, 18 had a peritoneal carcinomatosis index (PCI<\/jats:styled-content>) >7 and >3 LM<\/jats:styled-content> and median survival of 21.8 months compared with 18 patients with PCI<\/jats:styled-content> \u22647 and LM<\/jats:styled-content> \u22643 with median survival of 38.4 months. Median DFS<\/jats:styled-content> for A and B were 17.7 and 8.5 months respectively. Twenty\u2010seven in total experienced major complications following surgery. Sixty\u2010one patients recurred. Of A, 71.4% recurred compared with B at 86.1%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>While our study is limited, it has demonstrated encouraging evidence that long\u2010term survival outcomes can be achieved in this small but significant number of patients treated by CRS<\/jats:styled-content>\/IPC<\/jats:styled-content> and additional synchronous liver resection with no significant increase in morbidity when compared with CRS<\/jats:styled-content>\/IPC<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13231","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T16:23:27Z","timestamp":1436891007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Synchronous liver resection with cytoreductive surgery for the treatment of liver and peritoneal metastases from colon cancer: results from an Australian centre"],"prefix":"10.1111","volume":"87","author":[{"given":"Nayef","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Department of Surgery University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Surgical Oncology St George Hospital Sydney New South Wales Australia"},{"name":"College of Medicine Al\u2010Iman Muhammad Ibn Saud Islamic University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawson","family":"Ung","sequence":"additional","affiliation":[{"name":"Department of Surgery University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Surgical Oncology St George Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Valle","sequence":"additional","affiliation":[{"name":"Department of Surgery University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Surgical Oncology St George Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston","family":"Liauw","sequence":"additional","affiliation":[{"name":"Department of Surgery University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Surgical Oncology St George Hospital Sydney New South Wales Australia"},{"name":"Cancer Care Centre St George Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Surgical Oncology St George Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92529-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000197702.46394.16"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02274.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.03.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603033"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916280"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199804\/05)14:3<254::AID-SSU10>3.0.CO;2-U"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.640825"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25356"},{"key":"e_1_2_6_13_1","unstructured":"National Cancer Institute.National Cancer Institute Common Toxicity Criteria Version 2.1999.http:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/ctcmanual_v4_10\u20104\u201099.pdf. [Cited 05 July 2014]."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4473"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1039-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1517-y"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.03.013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.8467"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.3357"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032691"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.5390"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.1039"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13231","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.13231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:50:18Z","timestamp":1695502218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.13231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/ans.13231"],"URL":"https:\/\/doi.org\/10.1111\/ans.13231","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]},"assertion":[{"value":"2015-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}