{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:58:49Z","timestamp":1760061529473},"reference-count":20,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Combined cytoreductive surgery (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>) and perioperative intraperitoneal chemotherapy (<jats:styled-content style=\"fixed-case\">PIC<\/jats:styled-content>) has been considered as a standard approach for peritoneal surface malignancy. This study aims to assess the learning curve of this combined approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospectively collected data of our first 800 consecutive patients treated by <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIC<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 1996 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2014 were retrospectively reviewed. Eight hundred patients were divided into two groups and eight groups for comparison. A significant difference was defined as <jats:italic>P &lt;<\/jats:italic> 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant increase in the rate of the completeness of cytoreduction (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) score\u20100 from 74.0% to 83.0% was seen with a reduction in rates of other <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> scores. Also, there was a decreasing trend in mean blood transfusion units. The rate of viscus perforation, fistula formation and small bowel obstruction was significantly lower in the recent 400 patients. However, there was a significant increase in the incidence of deep venous thrombosis and pulmonary embolism. There was an improvement in the 5\u2010year survival rate for patients with colorectal cancer, pseudomyxoma peritonei and mesothelioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings demonstrate a learning curve associated with the combined approach of <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIC<\/jats:styled-content>. With adequate experience, <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PIC<\/jats:styled-content> can be safely performed with acceptable mortality and morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13280","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T04:00:15Z","timestamp":1441252815000},"page":"49-54","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis"],"prefix":"10.1111","volume":"87","author":[{"given":"Yeqian","family":"Huang","sequence":"first","affiliation":[{"name":"St George Clinical School University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayef A.","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Surgery St George Hospital  Sydney New South Wales Australia"},{"name":"College of Medicine Imam Muhammad ibn Saud Islamic University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winston","family":"Liauw","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology St George Hospital University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery St George Hospital University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21326"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5863"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181c9b53c"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181a45d86"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12197"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9406-8"},{"key":"e_1_2_7_9_1","first-page":"S119","article-title":"[Peritonectomy and chemohyperthermia in the treatment of peritoneal carcinomatosis: learning curve]","volume":"4","author":"Cavaliere F","year":"2004","journal-title":"Suppl. 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