{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:55:09Z","timestamp":1793040909872,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Background<\/jats:title>The management of congenital diaphragmatic hernia (CDH<\/jats:styled-content>) in neonates has evolved considerably over the last three decades. Initial stabilization followed by surgical repair is the current standard of care. A subset fails to achieve adequate oxygenation with medical management, including the use of high frequency oscillation and inhaled nitric oxide. The mortality in this group exceeds 80% without additional management strategies. Extracorporeal life support (ECLS<\/jats:styled-content>) is a well\u2010established modality for managing these neonates with CDH<\/jats:styled-content> and has been shown to improve early survival in selected cases.<\/jats:p><\/jats:sec>Methods<\/jats:title>This is a retrospective analysis of six neonates with CDH<\/jats:styled-content> who underwent repair during ECLS<\/jats:styled-content> between September 2011 and November 2014.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 24 admissions with CDH<\/jats:styled-content>, there were six neonates (25%) who required ECLS<\/jats:styled-content>. All the six had CDH<\/jats:styled-content> repair during ECLS<\/jats:styled-content>. There were no intra\u2010operative bleeding complications. There were no clotting complications related to stopping heparin during CDH<\/jats:styled-content> repair. There was one hospital death. Five neonates were weaned from ECLS<\/jats:styled-content> and discharged home.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Data from our small cohort of patients illustrate that early survival is possible in extremely compromised neonates who otherwise would have died without ECLS<\/jats:styled-content>. Our experience demonstrates that CDH<\/jats:styled-content> repair can safely be performed during ECLS<\/jats:styled-content>. Use of ECLS<\/jats:styled-content>, early repair during ECLS<\/jats:styled-content>, lung protective ventilation strategies and aggressive management of pulmonary hypertension were associated with good early survival. ECLS<\/jats:styled-content> should be considered as an integral part of therapeutic armamentarium for CDH<\/jats:styled-content> in neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13466","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:47:46Z","timestamp":1458348466000},"page":"711-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Repair of congenital diaphragmatic hernia during extracorporeal life support: experience with six neonates"],"prefix":"10.1111","volume":"86","author":[{"given":"Sudesh","family":"Prabhu","sequence":"first","affiliation":[{"name":"Queensland Paediatric Cardiac Service Lady Cilento Children's Hospital Brisbane Queensland Australia"},{"name":"University of Queensland Brisbane Queensland Australia"},{"name":"Mater Medical Research Institute Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian 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