{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:28:01Z","timestamp":1773026881157,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>While human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) is an accepted risk factor for oropharyngeal squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>), its aetiological role in oral cavity <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> remains unclear. This study aimed to determine the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> prevalence in an Australian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was extracted from 63 formalin\u2010fixed paraffin\u2010embedded tumour specimens histologically confirmed as <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the oral cavity, diagnosed during 2006\u20132012. Clinical data were extracted from medical records. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> presence was determined by polymerase chain reaction. Positive samples were typed by sequencing. Immunohistochemistry was used to assess <jats:styled-content style=\"fixed-case\">p16<jats:sup>INK4A<\/jats:sup>\n<\/jats:styled-content>, p53, <jats:styled-content style=\"fixed-case\">pRB<\/jats:styled-content>, Ki67, Cyclin <jats:styled-content style=\"fixed-case\">D1<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">p21<jats:sup>WAF1<\/jats:sup>\n<\/jats:styled-content> expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five of the 63 tumours (8%) were positive for <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content> (three <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u201016 positive and two <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u201018 positive). Two tumours overexpressed <jats:styled-content style=\"fixed-case\">p16<jats:sup>INK4A<\/jats:sup>\n<\/jats:styled-content> (3%) and one of these was also <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positive. Overexpression of Cyclin <jats:styled-content style=\"fixed-case\">D1<\/jats:styled-content> correlated significantly with tumour recurrence (<jats:italic>P<\/jats:italic> = 0.029) and death (<jats:italic>P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study has identified a low prevalence of high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> in Queensland, Australia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13607","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T02:30:56Z","timestamp":1461033056000},"page":"714-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Low prevalence of human papillomavirus in oral cavity squamous cell carcinoma in Queensland, Australia"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3102-6150","authenticated-orcid":false,"given":"Sarah","family":"Emmett","sequence":"first","affiliation":[{"name":"Department of Population Heath QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"Head and Neck Unit, Department of Otolaryngology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Head and Neck Unit, Department of Otolaryngology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Boros","sequence":"additional","affiliation":[{"name":"Department of Pathology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Whiteman","sequence":"additional","affiliation":[{"name":"Department of Population Heath QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict","family":"Panizza","sequence":"additional","affiliation":[{"name":"Head and Neck Unit, Department of Otolaryngology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Antonsson","sequence":"additional","affiliation":[{"name":"Department of Population Heath QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606091"},{"key":"e_1_2_6_3_1","volume-title":"Cancer in Queensland 1982 to 2012, Incidence, Mortality, Survival and Prevalence","author":"Registry, Q.C","year":"2014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26185"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23087"},{"key":"e_1_2_6_6_1","first-page":"829","article-title":"The diagnosis and treatment of oral cavity cancer","volume":"109","author":"Wolff KD","year":"2012","journal-title":"Dtsch. Arztebl. Int."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.09.008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0551"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2011.02.001"},{"key":"e_1_2_6_10_1","volume-title":"National Drug Strategy Household Survey detailed report: 2013","author":"AIHW","year":"2014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn025"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2012.873"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(83)80033-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-2-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1934"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.3.1013-1024.2005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3344"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.01.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.23"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.01.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4424"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1258\/00222150260369499"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-4-1057"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890460203"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg107"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.07.002"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.04.022"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.01.010"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70471-1"},{"key":"e_1_2_6_30_1","first-page":"889","article-title":"Role of human papillomavirus in oral tongue squamous cell carcinoma","volume":"12","author":"Elango KJ","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.04.010"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.5228"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1916-0216-42-23"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00078-0"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.01.021"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22851"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091761"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086023"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60809-0"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0033"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00476-08"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22980"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.13607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T10:35:17Z","timestamp":1695033317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.13607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/ans.13607"],"URL":"https:\/\/doi.org\/10.1111\/ans.13607","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,18]]},"assertion":[{"value":"2015-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}