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An ovine model of laryngeal injury has been developed, validated and utilized to examine laryngeal wound healing and the effect of a novel collagen inhibitor (halofuginone) on surgical wound healing. The study design includes basic research and animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An ovine laryngeal model was utilized to study controlled vocal fold injury and healing. Twenty\u2010five sheep were divided into five groups. Sheep underwent right <jats:styled-content style=\"fixed-case\">vocal fold<\/jats:styled-content> injury preceded or followed by administration of halofuginone orally, topically or intralesionally. Biopsies were taken at commencement, 1 month and larynges explanted at 3 months. Specimens were examined for elastin and collagen density and epithelial changes. Pearson correlation statistics and Student's <jats:italic>t<\/jats:italic>\u2010tests were used to assess inter\u2010relationships.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All sheep tolerated halofuginone. One sheep death occurred in an untreated sheep. <jats:styled-content style=\"fixed-case\">Vocal fold<\/jats:styled-content> tissue demonstrated a predictable histological response to injury. Elastin was significantly reduced post\u2010injury in the glottis. Halofuginone administered orally for 10 weeks prevented elastin loss and demonstrated a trend of reducing collagen density post\u2010injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In an ovine laryngeal injury model, administration of a fibrosis inhibitor resulted in altered elastin and collagen deposition after injury in the glottis. Further investigation is warranted to examine whether these tissue changes affect vocal fold dynamics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13852","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T09:48:47Z","timestamp":1479894527000},"page":"266-270","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Response of an ovine laryngeal injury model to a novel fibrosis inhibitor"],"prefix":"10.1111","volume":"87","author":[{"given":"Jacqueline","family":"Allen","sequence":"first","affiliation":[{"name":"Faculty of Medical and Health Science, Department of Surgery The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21058"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611501212"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800310"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.018366"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.013326"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21780"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700809"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700213"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900115"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00550.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2009.10.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2009\/08-0049)"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24707"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.3.1.11"},{"key":"e_1_2_7_17_1","first-page":"33","volume-title":"Morphometry","author":"Aherne W","year":"1982"},{"key":"e_1_2_7_18_1","first-page":"239","article-title":"Phonosurgery. 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