{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:34:36Z","timestamp":1785008076380,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pancreaticoduodenectomy is often required in patients with duodenal adenoma and adenocarcinoma and these patients generally have soft pancreatic texture and small pancreatic ducts, the two most significant factors associated with post\u2010operative pancreatic fistula (<jats:styled-content style=\"fixed-case\">POPF<\/jats:styled-content>). The aims of the study were to evaluate the rate of <jats:styled-content style=\"fixed-case\">POPF<\/jats:styled-content> and long\u2010term outcomes for patients with duodenal adenoma and adenocarcinoma who underwent curative resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study (2004\u20132014) examined patients treated surgically with non\u2010ampullary duodenal tumours (<jats:styled-content style=\"fixed-case\">NADTs<\/jats:styled-content>) in two <jats:styled-content style=\"fixed-case\">hepatopancreaticobiliary<\/jats:styled-content> units in Victoria, Australia, and Swansea, UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 49 resections performed including 33 pancreaticoduodenectomies, five pancreas\u2010preserving total duodenectomies and 11 segmental duodenal resections. Median length of follow\u2010up was 23.5 months. Final histopathology revealed 18 duodenal adenomas and 31 adenocarcinomas. <jats:styled-content style=\"fixed-case\">POPF<\/jats:styled-content> rate for <jats:styled-content style=\"fixed-case\">NADTs<\/jats:styled-content> was 28.9% (of which 54.5% were grade C) compared to 14.5% for all other pathologies. Grade C <jats:styled-content style=\"fixed-case\">POPF<\/jats:styled-content> was associated with poorer survival outcomes (hazard ratio = 6.73; <jats:italic>P<\/jats:italic> = 0.005). The 5\u2010year overall survival for patients with duodenal adenocarcinoma was 66.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Due to the soft pancreatic texture and small pancreatic duct, pancreatic resection for <jats:styled-content style=\"fixed-case\">NADTs<\/jats:styled-content> is associated with a high rate of <jats:styled-content style=\"fixed-case\">POPF<\/jats:styled-content> which contributes to reduced survival. Nevertheless, surgery is associated with favourable 5\u2010year survival compared to pancreatic resection for pancreatic adenocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13873","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:09:34Z","timestamp":1485389374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Surgical outcomes for duodenal adenoma and adenocarcinoma: a multicentre study in <scp>A<\/scp>ustralia and the <scp>U<\/scp>nited <scp>K<\/scp>ingdom"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-9924","authenticated-orcid":false,"given":"Chun Hin Angus","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery (Upper Gastrointestinal \u2013 Hepatopancreaticobiliary Service) Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Shingler","sequence":"additional","affiliation":[{"name":"Department of Surgery (Upper Gastrointestinal \u2013 Hepatopancreaticobiliary Service) Alfred Hospital  Melbourne Victoria Australia"},{"name":"Department of Pancreaticobiliary Surgery Morriston Hospital  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Mowbray","sequence":"additional","affiliation":[{"name":"Department of Pancreaticobiliary Surgery Morriston Hospital  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Al\u2010Sarireh","sequence":"additional","affiliation":[{"name":"Department of Pancreaticobiliary Surgery Morriston Hospital  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Surgery (Upper Gastrointestinal \u2013 Hepatopancreaticobiliary Service) Alfred Hospital  Melbourne Victoria Australia"},{"name":"Victorian HepatoPancreatoBiliary Surgery Group Cabrini Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marty","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgery (Upper Gastrointestinal \u2013 Hepatopancreaticobiliary Service) Alfred Hospital  Melbourne Victoria Australia"},{"name":"Victorian HepatoPancreatoBiliary Surgery Group Cabrini Hospital  Melbourne Victoria Australia"},{"name":"Department of Upper GI\/HPB Surgery Western Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val","family":"Usatoff","sequence":"additional","affiliation":[{"name":"Department of Surgery (Upper Gastrointestinal \u2013 Hepatopancreaticobiliary Service) Alfred Hospital  Melbourne Victoria Australia"},{"name":"Victorian HepatoPancreatoBiliary Surgery Group Cabrini Hospital  Melbourne Victoria Australia"},{"name":"Department of Upper GI\/HPB Surgery Western Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"Department of Surgery (Upper Gastrointestinal \u2013 Hepatopancreaticobiliary Service) Alfred Hospital  Melbourne Victoria Australia"},{"name":"Victorian HepatoPancreatoBiliary Surgery Group Cabrini Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.6.635"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2011.00292.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12078"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12186"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000997"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/404520"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2004.09.044"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.6970"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.05.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.09.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2012.00486.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i26.8691"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12184"},{"key":"e_1_2_7_15_1","first-page":"CD010583","article-title":"Prophylactic abdominal drainage for pancreatic surgery","author":"Peng S","year":"2015","journal-title":"Cochrane Database Syst. 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