{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:57:06Z","timestamp":1762001826001},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,16]],"date-time":"2017-04-16T00:00:00Z","timestamp":1492300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hashimoto's thyroiditis (<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>) is rarely on its own the indication for thyroidectomy. However, surgery in patients with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> will be undertaken when there is malignancy and may be required for pressure symptoms. Therefore, this study aimed to investigate the indications for surgery in <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Monash University Endocrine Surgery Database was analysed from 1994 to 2013 for patients with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>. Patients with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> were compared to a similar group of patients with no <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> on histopathology. Patient demographics, indication for surgery, histopathology, gland weight and complications were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2346 patients underwent total thyroidectomy during the study period. The median age was 55 years. Eleven percent of patients had <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> on final pathology (259\/2346). <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> patients reported more pressure symptoms, 25.5% compared to those with other pathology, 18.9% (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). Patients with pressure symptoms had heavier glands, 113\u2009g compared to 85\u2009g in those with other indications for surgery (<jats:italic>P<\/jats:italic>\u2009=\u20090.048). Within the <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> cohort, the median gland weight was 66\u2009g compared to 93\u2009g in those without <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). On multivariate analysis, pressure symptoms as an indication for surgery was associated with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), but age, gender and gland weight were not associated. In patients operated for pressure with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> as the only pathology, 90% had relief of pressure symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> were more likely to have pressure symptoms as an indication for surgery independent of gland weights.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13943","type":"journal-article","created":{"date-parts":[[2017,4,16]],"date-time":"2017-04-16T20:52:40Z","timestamp":1492375960000},"page":"359-362","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Total thyroidectomy for pressure symptoms in patients with <scp>H<\/scp>ashimoto's thyroiditis"],"prefix":"10.1111","volume":"88","author":[{"given":"Katrina","family":"Heggie","sequence":"first","affiliation":[{"name":"Department of Surgery The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Endocrine Surgery Unit Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meei","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Surgery The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Endocrine Surgery Unit Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Grodski","sequence":"additional","affiliation":[{"name":"Department of Surgery The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Endocrine Surgery Unit Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Endocrine Surgery Unit Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Serpell","sequence":"additional","affiliation":[{"name":"Department of Surgery The Alfred Hospital  Melbourne Victoria Australia"},{"name":"Endocrine Surgery Unit Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0384"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9485-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350206"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr030"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1996.6.445"},{"key":"e_1_2_5_7_1","first-page":"219","article-title":"Zur kenntniss der lymphomat\u00f6sen ver\u00e4nderung der schilddr\u00fcse (struma lymphomatosa)","volume":"97","author":"Hashimoto H","year":"1912","journal-title":"Arch. 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