{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:05:46Z","timestamp":1780358746530,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To assess pattern distribution and prognosis of the three anatomical entities of metastatic colorectal cancer, and influence of treatment of metastases on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients presenting with stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> colorectal cancer (synchronous group), or who developed metastatic recurrence (metachronous group) after initial curative treatment between January 2005 and August 2015 were reviewed. Right sided (cecum to transverse colon), left sided (splenic flexure to sigmoid colon) and rectal cancers were identified. Distribution of metastases were noted as hepatic, lung or peritoneal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 374 patients, 276 were synchronous, 98 were metachronous. Metachronous group had a better 3\u2010year survival (54%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 42\u201364 versus 33%, <jats:styled-content style=\"fixed-case\">95% CI<\/jats:styled-content>: 27\u201339, log rank <jats:italic>P<\/jats:italic>\u2009=\u20090.0038). There were equal numbers of right (<jats:italic>n<\/jats:italic>\u2009=\u2009119), left (<jats:italic>n<\/jats:italic>\u2009=\u2009115) and rectal cancers (<jats:italic>n<\/jats:italic>\u2009=\u2009140). Rectal cancers had a higher metastatic recurrence, yet demonstrated better 3\u2010year survival (right colon 45%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 19\u201367, left colon 49%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 27\u201368, rectum 59%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 42\u201372, <jats:italic>P<\/jats:italic>\u2009=\u20090.39) due to higher proportions of metachronous patients undergoing treatment for metastases (40 versus 14%). Over half of all organ metastases spread to liver, with equal distribution from all three anatomical groups. Rectal cancers showed highest preponderance for lung metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rectal cancers have a higher chance of recurring, with a higher metastatic rate to the lung, yet demonstrate better survival outcomes in metastatic colorectal cancer, reflecting the benefit of intervention for metastases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.13969","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:56:46Z","timestamp":1494982606000},"page":"445-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Influence of primary site on metastatic distribution and survival in stage <scp>IV<\/scp> colorectal cancer"],"prefix":"10.1111","volume":"88","author":[{"given":"Arul E.","family":"Suthananthan","sequence":"first","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Platell","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"755","article-title":"Distinguishing right from left colon by the pattern of gene expression","volume":"12","author":"Glebov OK","year":"2003","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"e_1_2_6_3_1","first-page":"2308","article-title":"Classifying early\u2010onset colorectal cancer according to tumor location: new potential subcategories to explore","volume":"5","author":"Perea J","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25258"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02549.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo_00000720"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234734"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B0820273"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.12.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.02.093"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000160703.75808.7d"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000138076.72547.b1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.098053"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950801)76:3<393::AID-CNCR2820760308>3.0.CO;2-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.07.009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b4539b"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181c703a4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6130"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000120628"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-688"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0015-y"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181a7b7de"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0031"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1454-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181dcadbc"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12488"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2015.08.001"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.02.017"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.11.004"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.125165"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02719380"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.02.027"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1951-5"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.10.023"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.13969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.13969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:43:57Z","timestamp":1695494637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.13969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/ans.13969"],"URL":"https:\/\/doi.org\/10.1111\/ans.13969","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]},"assertion":[{"value":"2016-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}