{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:58:32Z","timestamp":1775743112144,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lottery Grants Board"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although many clinical prediction rules (<jats:styled-content style=\"fixed-case\">CPRs<\/jats:styled-content>) for appendicitis exist, none have been developed for a New Zealand population presenting with right iliac fossa (<jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content>) pain. The aim of this study was to derive and validate an appendicitis <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> for our population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a retrospective review of all patients from December 2010 to February 2012 of at least 15\u2009years of age presenting to the general surgery service with <jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content> pain. Patient data were divided into derivation and validation groups. Univariate and multiple regression analyses identified significant predictors of appendicitis which were used to construct a <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>. A retrospective validation study was then performed and the <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> was refined accordingly. Finally, the accuracy of the <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> was tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final components of the new <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">APPEND<\/jats:styled-content> score, were <jats:italic>A<\/jats:italic>norexia, migratory <jats:italic>P<\/jats:italic>ain, local <jats:italic>P<\/jats:italic>eritonism, <jats:italic>E<\/jats:italic>levated C\u2010reactive protein, <jats:italic>N<\/jats:italic>eutrophilia and male gender (<jats:italic>D<\/jats:italic>ude). This <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> has an area under the receiver operating characteristic curve of 0.84. The <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> can stratify patients into low, intermediate and high\u2010risk groups which may standardize patient care and reduce the negative appendicectomy rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A new <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> for predicting appendicitis, in patients presenting with <jats:styled-content style=\"fixed-case\">RIF<\/jats:styled-content> pain, has been derived and validated for use in our population. A prospective study to further evaluate its performance is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14022","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:56:46Z","timestamp":1494982606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Derivation and validation of the <scp>APPEND<\/scp> score: an acute appendicitis clinical prediction rule"],"prefix":"10.1111","volume":"88","author":[{"given":"Hinetamatea","family":"Mikaere","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Zeng","sequence":"additional","affiliation":[{"name":"Research and Evaluation Office Health Intelligence and Informatics, Ko Awatea, Counties Manukau Health  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Lauti","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malsha","family":"Kularatna","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"MacCormick","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"},{"name":"Department of Surgery Middlemore Hospital, Counties Manukau Health  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.07.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/730167"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3416-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000231726.53487.dd"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31821ad9c4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200104000-00001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1856-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-008-0116-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588408X285973"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2008.01.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091570"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31826a9602"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2013.03.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-3-200602070-00009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(86)80993-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-005-0545-8"},{"key":"e_1_2_7_18_1","first-page":"220","article-title":"Development of the RIPASA score: a new appendicitis scoring system for the diagnosis of acute appendicitis","volume":"51","author":"Chong CF","year":"2010","journal-title":"Singap. 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