{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:45:28Z","timestamp":1790696728951,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenal incidentalomas are increasingly diagnosed and include a wide spectrum of lesions from benign adenomas to secreting or malignant lesions. The aim of the present study is to report a large single\u2010institution experience of patients undergoing surgery for adrenal incidentaloma with particular attention to their diagnosis and post\u2010operative course and the evolution of surgical practice over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 1993 to 2013, 274 patients underwent adrenalectomy for incidentaloma. All patients underwent standardized clinical, hormonal and imaging assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were mainly female (63.1%; <jats:italic>n<\/jats:italic>\u2009=\u2009173), and the median age of patients was 56.5\u2009years. After a complete hormonal evaluation, 47.9% (<jats:italic>n<\/jats:italic>\u2009=\u2009129) of incidentalomas were classified as secreting tumours, including 24.4% (<jats:italic>n<\/jats:italic>\u2009=\u200967) subclinical cortisol\u2010secreting adenomas and 18.9% (<jats:italic>n<\/jats:italic>\u2009=\u200952) pheochromocytomas. Adrenocortical carcinomas represented 9.5% (<jats:italic>n<\/jats:italic>\u2009=\u200926) of incidentalomas, and the risk of malignancy was significantly correlated with tumour size. The conversion rate after laparoscopic adrenalectomy (90.9%; <jats:italic>n<\/jats:italic>\u2009=\u2009249) was 3.2% (<jats:italic>n<\/jats:italic>\u2009=\u20098). The overall morbidity rate was 13.9%, which included a 4.4% rate of severe morbidity (Clavien\u2013Dindo\u2009\u22653). From 2008 onwards, there was a significant decrease (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in the use of surgical approaches for non\u2010secreting adenomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After a complete work\u2010up, half of the incidentalomas were classified as subclinical oversecreting adrenal lesions and 10% proved to be malignant adrenocortical carcinomas. The debatable use of surgical approaches for benign nonfunctioning adenomas significantly decreased over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14095","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T23:56:44Z","timestamp":1499471804000},"page":"468-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adrenalectomy for incidentaloma: lessons learned from a single\u2010centre series of 274 patients"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-7639","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Gaujoux","sequence":"first","affiliation":[{"name":"Department of Digestive, Hepatobiliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital APHP  Paris France"},{"name":"Paris Descartes Medical School, University Paris Descartes Sorbonne Paris Cit\u00e9  Paris France"},{"name":"INSERM Unit 1016, CNRS UMR 8104 Institute Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Aim\u00e9","sequence":"additional","affiliation":[{"name":"Department of Digestive, Hepatobiliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Assi\u00e9","sequence":"additional","affiliation":[{"name":"Paris Descartes Medical School, University Paris Descartes Sorbonne Paris Cit\u00e9  Paris France"},{"name":"INSERM Unit 1016, CNRS UMR 8104 Institute Cochin  Paris France"},{"name":"Department of Endocrinology, Referral Center for Rare Adrenal Diseases, Cochin Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ciuni","sequence":"additional","affiliation":[{"name":"Department of Digestive, Hepatobiliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Digestive, Hepatobiliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital APHP  Paris France"},{"name":"Paris Descartes Medical School, University Paris Descartes Sorbonne Paris Cit\u00e9  Paris France"},{"name":"INSERM Unit 1016, CNRS UMR 8104 Institute Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Tenenbaum","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Cochin Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Bertherat","sequence":"additional","affiliation":[{"name":"Paris Descartes Medical School, University Paris Descartes Sorbonne Paris Cit\u00e9  Paris France"},{"name":"INSERM Unit 1016, CNRS UMR 8104 Institute Cochin  Paris France"},{"name":"Department of Endocrinology, Referral Center for Rare Adrenal Diseases, Cochin Hospital APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Dousset","sequence":"additional","affiliation":[{"name":"Department of Digestive, Hepatobiliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital APHP  Paris France"},{"name":"Paris Descartes Medical School, University Paris Descartes Sorbonne Paris Cit\u00e9  Paris France"},{"name":"INSERM Unit 1016, CNRS UMR 8104 Institute Cochin  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-5-200303040-00013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490273"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.15.S1.1"},{"key":"e_1_2_5_5_1","unstructured":"TerzoloM StiglianoA ChiodiniIet al. 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