{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:18:54Z","timestamp":1768821534148,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T00:00:00Z","timestamp":1502582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National University Health System Pitch for Funds"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Background<\/jats:title>Diffusion\u2010weighted (DW<\/jats:styled-content>) imaging is a functional magnetic resonance imaging (MRI<\/jats:styled-content>) technique that detects lesions with high cellularity, such as malignant tumours. This prospective study was performed to compare the accuracy of DW\u2010MRI<\/jats:styled-content> with multidetector computed tomography (MDCT<\/jats:styled-content>) in staging of colorectal cancer.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty patients with histologically proven colorectal cancer were prospectively recruited. Each patient underwent both MDCT<\/jats:styled-content> and DW\u2010MRI<\/jats:styled-content> of the abdomen\u2013pelvis for primary staging. Images were evaluated for nodal and distant metastases. The reference standard was histopathological findings for nodal involvement and surveillance imaging for suspected hepatic metastases.<\/jats:p><\/jats:sec>Results<\/jats:title>The primary cancers were located in the rectum (n<\/jats:italic> = 16, 53.3%), sigmoid colon (n<\/jats:italic> = 9, 30%) and right colon (n<\/jats:italic> = 5, 16.6%). For nodal metastases, the sensitivity and specificity of DW\u2010MRI<\/jats:styled-content> were 84.6% (95% confidence interval (CI<\/jats:styled-content>): 54.6\u201398.1%) and 20.0% (95% CI<\/jats:styled-content>: 2.5\u201355.6%) compared with 84.6% (95% CI<\/jats:styled-content>: 54.6\u201398.1%) and 40.0% (95% CI<\/jats:styled-content>: 12.2\u201373.8%) for MDCT<\/jats:styled-content>. For liver metastases, the sensitivity and specificity for DW\u2010MRI<\/jats:styled-content> were 100.0% (95% CI<\/jats:styled-content>: 63.1\u2013100.0%) and 100% (95% CI<\/jats:styled-content>: 84.6\u2013100%) compared with 87.5% (95% CI<\/jats:styled-content>: 47.4\u201399.7%) and 95.5% (95% CI<\/jats:styled-content>: 77.2\u201399.9%) for MDCT<\/jats:styled-content>. DW<\/jats:styled-content> imaging altered the clinical management in three (10.0%) patients by detecting missed hepatic metastases in two patients and accurately diagnosing another patient with a hepatic cyst, mistaken for metastasis on MDCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>\nDW\u2010MRI<\/jats:styled-content> is more accurate for detecting hepatic metastases in colorectal cancer compared with MDCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14138","type":"journal-article","created":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T23:52:42Z","timestamp":1502668362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prospective comparison between magnetic resonance imaging and computed tomography in colorectal cancer staging"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3717-4480","authenticated-orcid":false,"given":"Frederick H. X.","family":"Koh","sequence":"first","affiliation":[{"name":"Division of Colorectal Surgery, University Surgical Cluster, National University Hospital National University Health System Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ker\u2010Kan","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, University Surgical Cluster, National University Hospital National University Health System Singapore"},{"name":"Department of Surgery, Yong Loo Lin School of Medicine National University of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette L. S.","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, National University Hospital National University Health System Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand W. L.","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, National University Hospital National University Health System Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee\u2010Liang","family":"Thian","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, National University Hospital National University Health System Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1403"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.10.027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463070432"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3279"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.08.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3477-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.143.8.743"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<229::AID-CNCR6>3.0.CO;2-C"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1753"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01229.x"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.14138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.14138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T09:27:54Z","timestamp":1715765274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.14138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,13]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/ans.14138"],"URL":"https:\/\/doi.org\/10.1111\/ans.14138","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,13]]},"assertion":[{"value":"2017-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}