{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:07:30Z","timestamp":1782832050766,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Low anterior resection syndrome (<jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content>) covers disordered bowel function after rectal resection, leading to deterioration in patients\u2019 quality of life. The aim of this study was to evaluate anorectal function after laparoscopic low anterior resection (<jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content>) by means of standardized instruments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective clinical cohort study conducted in a single institution to assess functional outcome of patients 1 year after laparoscopic <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> by means of <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> score and high\u2010resolution anorectal manometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 65 patients were enrolled in the study. Mean tumour height was 9.4 \u00b1 1.8 cm; total mesorectal excision during laparoscopic <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> with low end\u2010to\u2010end colorectal anastomosis was performed in all patients. One year after the surgery, minor <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> was detected in 33.9% of patients, major <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> in 36.9% of patients. Anorectal manometry revealed decreased resting pressure and normal squeeze pressure of the anal sphincters in the majority of our patients. Rectal compliance and rectal volume tolerability (first sensation, urge to defaecate and discomfort volume) were significantly reduced. The statistical testing of the correlation between <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> and manometry parameters showed that with increasing seriousness of <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content>, values of some parameters (resting pressure, first sensation, urge to defaecate, discomfort volume and rectal compliance) were reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicates that the majority of patients after laparoscopic <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> experience symptoms of minor or major <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content>. These patients have decreased resting anal sphincter pressures, decreased rectal volume tolerability and decreased rectal compliance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14207","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T23:52:39Z","timestamp":1505778759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Functional outcome of low rectal resection evaluated by anorectal manometry"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-6257","authenticated-orcid":false,"given":"Peter","family":"Ihn\u00e1t","sequence":"first","affiliation":[{"name":"Department of Surgical Studies, Faculty of Medicine University of Ostrava  Ostrava Czech Republic"},{"name":"Department of Surgery University Hospital Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"V\u00e1vra","sequence":"additional","affiliation":[{"name":"Department of Surgical Studies, Faculty of Medicine University of Ostrava  Ostrava Czech Republic"},{"name":"Department of Surgery University Hospital Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Prokop","sequence":"additional","affiliation":[{"name":"Department of Surgical Studies, Faculty of Medicine University of Ostrava  Ostrava Czech Republic"},{"name":"Department of Surgery University Hospital Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Pelik\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Surgical Studies, Faculty of Medicine University of Ostrava  Ostrava Czech Republic"},{"name":"Department of Surgery University Hospital Ostrava  Ostrava Czech Republic"},{"name":"Faculty of Humanities Tomas Bata University  Zlin Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Ihn\u00e1t Rudinsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine University Hospital Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Penka","sequence":"additional","affiliation":[{"name":"Department of Surgical Studies, Faculty of Medicine University of Ostrava  Ostrava Czech Republic"},{"name":"Department of Surgery University Hospital Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-014-2528-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2011.05.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9402-z"},{"key":"e_1_2_6_5_1","first-page":"CD004323","article-title":"Quality of life after rectal resection for cancer, with or without permanent colostomy","volume":"12","author":"Pachler JP","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2013.09.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-012-0909-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.t01-1-00503.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0807-y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.136.2.192"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-007-0322-y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.00439.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.3.257"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800691019"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31824f1c21"},{"key":"e_1_2_6_16_1","first-page":"524","article-title":"3D High resolution anorectal manometry in functional anorectal evaluation","volume":"93","author":"Ihn\u00e1t P","year":"2014","journal-title":"Rozhl. Chir."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70236-X"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12244"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0699-y"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02054232"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760805"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740804"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02047876"},{"key":"e_1_2_6_25_1","first-page":"1584","article-title":"A pathophysiological study using anorectal manometry on patients with or without soiling 5 years or more after low anterior resection for lower rectal cancer","volume":"55","author":"Tomita R","year":"2008","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2003.12.064"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80124-X"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2005.46.6.737"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800640820"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0296-1"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.9017"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.5264"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.14207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.14207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T09:28:37Z","timestamp":1715765317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.14207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/ans.14207"],"URL":"https:\/\/doi.org\/10.1111\/ans.14207","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]},"assertion":[{"value":"2017-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}