{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:50:27Z","timestamp":1790607027701,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002736","name":"Covidien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011371","name":"Royal Australasian College of Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Radical surgical resection is the mainstay of curative treatment for oesophagogastric malignancy. However, survival and recurrence rates remain poor. Theoretical data suggests that the inflammatory response to surgery can promote tumour recurrence. The local and systemic inflammatory response to radical oesophagogastric cancer surgery has not been fully characterized. We aimed to measure this response, particularly factors associated with tumour implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients undergoing radical junctional or gastric cancer resection over 12 months were recruited. Repeated serum and adipose tissue were collected intra\u2010operatively. Adipose tissue was collected adjacent and remote to the tumour, and cytokine messenger RNA (<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>) expression was measured. Post\u2010operatively, daily serum was collected for 7 days, and analysed for inflammatory cell profile and cytokine concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were nine patients recruited (67.1 \u00b1 2.1 years). <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106), CC\u2010chemokine ligand\u20102 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 increased in adipose tissue intra\u2010operatively (<jats:italic>P<\/jats:italic> &lt; 0.05), equally both adjacent and remote from the tumour site. Serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 concentration increased from 23.3 pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> to 161.8 pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> intra\u2010operatively (<jats:italic>P<\/jats:italic> &lt; 0.05) before falling steadily to 35.7 pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> post\u2010operatively (<jats:italic>P<\/jats:italic> &lt; 0.05). Serum tumour necrosis factor\u2010\u03b1 was elevated throughout, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 levels were unaffected. Leukocyte and neutrophil populations increased, while T\u2010cell and dendritic cell populations decreased intra\u2010operatively (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radical surgery dramatically upregulates the expression of pro\u2010tumourigenic cytokines in the peritoneum. There is also a marked systemic immune and inflammatory response to surgery, including downregulation of T\u2010cell and dendritic cell populations. This offers two potential pathways that may facilitate tumour progression \u2013 local inflammation promoting peritoneal adherence and implantation, and secondary suppression of immunosurveillance due to circulating inflammatory response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14267","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T01:22:40Z","timestamp":1512091360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Radical gastric cancer surgery results in widespread upregulation of pro\u2010tumourigenic intraperitoneal cytokines"],"prefix":"10.1111","volume":"88","author":[{"given":"Andrew J.","family":"Long","sequence":"first","affiliation":[{"name":"Centre for Obesity Research and Education Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Burton","sequence":"additional","affiliation":[{"name":"Centre for Obesity Research and Education Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"De Veer","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-408X","authenticated-orcid":false,"given":"Geraldine J.","family":"Ooi","sequence":"additional","affiliation":[{"name":"Centre for Obesity Research and Education Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl P.","family":"Laurie","sequence":"additional","affiliation":[{"name":"Centre for Obesity Research and Education Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Nottle","sequence":"additional","affiliation":[{"name":"Department of Upper Gastrointestinal Surgery The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Physiology Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Centre for Obesity Research and Education Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70070-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2283-2291.1997"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.11.1132"},{"key":"e_1_2_7_5_1","first-page":"429","article-title":"Imbalance of circulating T\u2010lymphocyte subpopulation in gastric cancer patients correlated with performance status","volume":"59","author":"Wang L","year":"2013","journal-title":"Clin. 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