{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:49:01Z","timestamp":1782949741735,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The painful post amputation neuroma significantly impairs the prosthesis\u2010wearing lower\u2010limb amputee. It remains poorly understood, with literature limited to cohorts of traumatic amputees. This paper reports the incidence and associations of painful neuroma in a modern tertiary centre with a case load of amputations performed for both traumatic and non\u2010traumatic indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective cohort study analysed the records of 304 patients who underwent all\u2010cause lower\u2010limb amputation at The Alfred Hospital between January 2002 and March 2012. Patients were included in our analysis if they completed 1\u2010year follow\u2010up at our Amputee Rehabilitation Clinic, producing a final cohort of 96 patients. In order to identify a painful neuroma post\u2010operatively, both clinical suspicion, and either histopathological or radiological evidence were required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall incidence of symptomatic neuromas was 4.17%. There was no significant difference between patients who underwent amputation for a traumatic indication (6.25% (2\/32) versus 3.13% (2\/64); <jats:italic>P<\/jats:italic>\u2009=\u20090.59) compared to non\u2010traumatic indication (<jats:italic>P<\/jats:italic>\u2009=\u20090.59). Visual analogue score at discharge and the presence of phantom limb pain at follow\u2010up showed significant associations with the formation of painful neuroma. Dose of opioid on discharge, history of depression and current smoking did not reach statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study presents a lower incidence of painful post\u2010amputation neuroma to those published in the literature. This may be attributed to improved methodology. The described associations require further investigation into central factors leading to neuroma sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14293","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T07:26:23Z","timestamp":1523690783000},"page":"491-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Incidence and associations of painful neuroma in a contemporary cohort of lower\u2010limb amputees"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-294X","authenticated-orcid":false,"given":"Anthony","family":"Penna","sequence":"first","affiliation":[{"name":"Department of Plastic, Hand and Faciomaxillary Surgery Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H.","family":"Konstantatos","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine Alfred Hospital  Melbourne Victoria Australia"},{"name":"Faculty of Medicine, Nursing and Health Sciences, Monash University  Melbourne Victoria Australia"},{"name":"Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Cranwell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldho","family":"Paul","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Clinical Haematology Department Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco\u2010Raffaele","family":"Bruscino\u2010Raiola","sequence":"additional","affiliation":[{"name":"Department of Plastic, Hand and Faciomaxillary Surgery Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-007-0466-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21607"},{"key":"e_1_2_7_4_1","first-page":"600","article-title":"MRI and nerve stump neuroma","volume":"44","author":"Martinet N","year":"2001","journal-title":"Ann. 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