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The aim of this study is to systematically review the current literature to determine their role in predicting survival outcomes in GBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a pre\u2010specified inclusive search strategy MEDLINE, EMBASE and CINAHL databases were used to identify studies describing survival in patients after GBC resection with high or low pre\u2010operative CRP, GPS or NLR. A proforma was used to extract study author and date, number of patients, age, gender, tumour stage, use of adjuvant therapy and primary outcome data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 46 studies were identified after initial screening with four studies reporting survival outcomes. All studies described a reduction in survival in patients with an elevated NLR, GPS or CRP. Three studies showed NLR to be an independent prognostic marker and one study additionally demonstrated that elevated CRP and GPS were associated with poorer survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated pre\u2010operative inflammatory markers are inversely related to survival outcomes. They are relatively inexpensive, easy measurable parameters that could aid in the decision making process involved in the management of GBC. Sub\u2010stratification of groups utilizing inflammatory markers may help guide surgical strategy. However, these studies are retrospective and of low to moderate quality. High quality, prospective studies with well\u2010defined inclusion criteria and outcomes are needed to guide the role of inflammatory markers in the management of GBC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14300","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T10:22:01Z","timestamp":1512469321000},"page":"554-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic significance of pre\u2010operative inflammatory markers in resected gallbladder cancer: a systematic review"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9885-0921","authenticated-orcid":false,"given":"Rukhtam","family":"Saqib","sequence":"first","affiliation":[{"name":"Department of HPB Surgery Bristol Royal Infirmary  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery Bristol Royal Infirmary  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Smart","sequence":"additional","affiliation":[{"name":"Exeter Surgical Health Services Research Unit Royal Devon and Exeter NHS Foundation Trust  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery University Hospital Aintree  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rees","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery Bristol Royal Infirmary  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Finch Jones","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery Bristol Royal Infirmary  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Poston","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery University Hospital Aintree  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,3]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Cancer Research UK.Gallbladder Cancer Incidence Statistics. 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