{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T19:08:10Z","timestamp":1775761690498,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T00:00:00Z","timestamp":1517616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to explore the effects of early antiplatelet therapy (APT) for portal vein thrombosis (PVT) in patients with cirrhotic portal hypertension after splenectomy with gastro\u2010oesophageal devascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed 139 patients who underwent splenectomy with gastro\u2010oesophageal devascularization for portal hypertension due to cirrhosis between April 2010 and December 2016. Based on the post\u2010operative platelet values, we used two different APT regimens: APT was started when platelet counts were increased to 200\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L or above (group A, <jats:italic>n<\/jats:italic>\u2009=\u200964) or 300\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L or above (group B, <jats:italic>n<\/jats:italic>\u2009=\u200975). We took note of the patients\u2019 clinical symptoms, operative factors and biochemical indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Platelet count, mean platelet volume, D\u2010dimer and pancreatic fistula were closely related to the development of PVT. Early APT was an independent protective factor for PVT. The incidence of post\u2010operative PVT was 15.1% (21\/139) overall, 4.7% (3\/64) in group A and 24% (18\/75) in group B; there was a significant difference between groups A and B (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200910.042, <jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platelet count, mean platelet volume, D\u2010dimer and pancreatic fistula were independent risk factors for the development of PVT after splenectomy with gastro\u2010oesophageal devascularization. Selection of the appropriate timing for early APT according to the post\u2010operative platelet count was feasible. Moreover, the use of aspirin combined with dipyridamole was safe and effective for early prevention of PVT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14395","type":"journal-article","created":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T07:18:48Z","timestamp":1517642328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of early antiplatelet therapy after splenectomy with gastro\u2010oesophageal devascularization"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1485-2226","authenticated-orcid":false,"given":"Jin\u2010Bao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of General Surgery The Third Affiliated Hospital of Soochow University  Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao\u2010Yang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Third Affiliated Hospital of Soochow University  Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Third Affiliated Hospital of Soochow University  Changzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Sir Run Run Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"4236","article-title":"Predictive model of portal venous system thrombosis in cirrhotic portal hypertensive patients after splenectomy","volume":"8","author":"He S","year":"2015","journal-title":"Int. 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