{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:22:11Z","timestamp":1780341731971,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Peritoneal metastasis (PM) following primary resection of colorectal cancer is common. The combined use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy has significantly improved the survival outcome of patients with colorectal PM (CRPM). Diagnosing and treating early PM is essential as its extent is correlated with poorer outcomes. There are two novel therapies \u2013 second\u2010look surgery and synchronous hyperthermic intraperitoneal chemotherapy \u2013 that are proposed to prophylactically treat or intervene early in the disease process to reduce the incidence and adverse outcomes associated with PM. These strategies are limited to patients at high risk of developing CRPM, including those that had synchronous PM or ovarian metastases resected at primary tumour removal, or a perforated primary tumour. The data on advanced primary tumour (T4) as a prognostic factor for PM after primary resection suggest that T4a tumours are prognostically worse than T4b. This literature review outlines the evidence, feasibility and safety regarding the pre\u2010emptive treatments, as well as the relevance of T4a tumours as a risk factor for metachronous CRPM.<\/jats:p>","DOI":"10.1111\/ans.14428","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:06:45Z","timestamp":1520381205000},"page":"975-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevention of peritoneal recurrence in high\u2010risk colorectal cancer and evidence of T4 status as a potential risk factor"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-3799","authenticated-orcid":false,"given":"Lee Shyang","family":"Kyang","sequence":"first","affiliation":[{"name":"Department of Surgery, St George Hospital The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Valle","sequence":"additional","affiliation":[{"name":"Department of Surgery, St George Hospital The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayef A.","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Surgery, St George Hospital The University of New South Wales  Sydney New South Wales Australia"},{"name":"College of Medicine Al Imam Muhammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery, St George Hospital The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000197702.46394.16"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8679"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.82"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-016-0499-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1245-1_9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.23.2831"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i39.5489"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.01.017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31815f0113"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31822638f6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i41.6979"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900560"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010701)92:1<71::AID-CNCR1293>3.0.CO;2-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7800-2-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2015.01.002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4387-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-010-0567-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.10.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3461-0"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/141585"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089161309900505"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5488-5"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/529876"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-9946-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.06.012"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.369"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603646"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-9941.158965"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9571-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1430-7"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1475-x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5345"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2006.08.003"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-010-0934-5"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(11)71675-6"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2183-4"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28676"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70119-7"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02274.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds173"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2473-5"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2015.08.161"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12552"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13219"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fans.14428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.14428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T01:44:39Z","timestamp":1694915079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.14428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,6]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/ans.14428"],"URL":"https:\/\/doi.org\/10.1111\/ans.14428","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,6]]},"assertion":[{"value":"2017-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}