{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:09:50Z","timestamp":1780384190831,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>The aim of this study was to systematically analyse and perform a meta\u2010analysis on the current available literature comparing the fusion rates and complications associated with use of autograft, allograft and bone substitutes to supplement posterior spinal fusion for adolescent idiopathic scoliosis (AIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The electronic databases including Embase, PubMed, Medline, Cinahl and Cochrane Library were searched to identify relevant studies. A total of 12 studies with 2389 patients were included for meta\u2010analysis. The primary outcome was fusion rate, while the secondary outcomes included blood loss, operation time, infection rates and post\u2010operative pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The current meta\u2010analysis found no difference in fusion rates between groups with an overall fusion rate of 100% (95% confidence interval (CI) 0.99\u20131.00; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Total estimated blood loss was significantly higher in the iliac crest bone graft (ICBG) group compared with control group (1018 versus 861\u2009mL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In addition, the mean operative time was significantly higher in the ICBG group (259 versus 237\u2009min; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The ICBG group also had increased post\u2010operative pain issues compared with the control group (26 versus 9%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). There was no significant difference in terms of post\u2010operative wound infection between groups with an overall infection rate of 1% (95% CI 0.0\u20130.02; <jats:italic>P<\/jats:italic>\u2009=\u20090.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICBG confers no advantage over the other graft options in achieving fusion in AIS surgery. Furthermore, crest harvesting was associated with significant increases in blood loss, operative time and post\u2010operative pain issues. Therefore, allograft and bone substitutes are attractive alternatives to autogenous grafting during posterior fusion in AIS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14551","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T23:51:47Z","timestamp":1526428307000},"page":"1247-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Bone graft in posterior spine fusion for adolescent idiopathic scoliosis: a meta\u2010analysis"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-0710","authenticated-orcid":false,"given":"Nathan","family":"Kirzner","sequence":"first","affiliation":[{"name":"Orthopaedic Department Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Hilliard","sequence":"additional","affiliation":[{"name":"Orthopaedic Department Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery and Orthopaedics Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Liew","sequence":"additional","affiliation":[{"name":"Orthopaedic Department Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Humadi","sequence":"additional","affiliation":[{"name":"Orthopaedic Department Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11832-012-0457-4"},{"key":"e_1_2_7_3_1","first-page":"4","article-title":"A report of fifty\u2010nine cases of scoliosis treated by the fusion operation. 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