{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:18:30Z","timestamp":1785014310657,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study was conducted to evaluate the efficacy and necessity of repeat transurethral resection (re\u2010TUR) treatment for selected patients with muscle\u2010invasive bladder cancer and to investigate the possibility of bladder sparing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 61 selected patients with invasive bladder cancer who were treated by re\u2010TUR and in whom biopsies of the muscle layer of the tumour bed were negative. Re\u2010TUR was performed within 4\u20136 weeks of the initial resection. Pirarubicin instillation was scheduled for the bladder\u2010preserving group. The prognosis was compared with that of patients in our previous research, which included 93 selected patients with invasive bladder cancer who were treated by radical TUR. In that research, we found that the overall survival and disease\u2010specific survival rates were 59.1 and 65.2%, respectively. The clinical stage of tumour influenced the survival rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 61 patients who underwent re\u2010TUR, 31 never had disease relapse, 19 had disease recurrence and 11 had disease progression. The clinical stage of the tumour influenced the overall survival and disease\u2010specific survival. The 5\u2010year overall survival rate was 70% and disease\u2010specific survival rate was 74%, respectively. Compared with the TUR group, both the overall survival and disease\u2010specific survival rates of the re\u2010TUR group both increased significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Re\u2010TUR combined with pirarubicin instillation is a suitable bladder\u2010preserving treatment for selected patients with muscle\u2010invasive bladder cancer, based on good overall survival and disease\u2010specific survival rates demonstrated in this research. The clinical stage of tumour has a major influence on the survival rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14709","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T09:05:19Z","timestamp":1530781519000},"page":"1033-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Value of repeat radical transurethral resection for selected patients with muscle\u2010invasive bladder cancer"],"prefix":"10.1111","volume":"88","author":[{"given":"Zhuo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7817-4586","authenticated-orcid":false,"given":"Yuanwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Urology Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.023"},{"key":"e_1_2_6_3_1","first-page":"2895","article-title":"Survival following transurethral resection of bladder carcinoma","volume":"37","author":"Barnee RW","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41899-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000455572","article-title":"Transurethral resection for the assessment and treatment of vesical neoplasms: a review of 840 consecutive cases","volume":"1","author":"O'Flynn JD","year":"1975","journal-title":"Eur. 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