{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:41:58Z","timestamp":1789141318178,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anal squamous cell carcinoma (SCC) is a rare malignancy. The purpose of this study was to review a single institution's experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with anal SCC from St John of God Subiaco Hospital database were identified over a 10\u2010year period (2006\u20132016). Patients with stage 1 anal verge tumours underwent wide local excision, all remaining patients were offered chemoradiation (CRT) as an initial treatment modality (a fluorouracil\u2010based regimen in conjunction with mitomycin). Outcomes included recurrence, overall survival and survival following salvage surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven patients were identified. Median age was 60\u2009years and median follow\u2010up was 2.73\u2009years. Five\u2010year rates of recurrence and overall survival were 35.8% (95% confidence interval (CI) 23.2\u201352.4%) and 65.4% (95% CI 47.0\u201378.7%), respectively. Locoregional failure occurred most commonly at the primary site. Eight patients underwent salvage abdominoperineal resection for persistent or recurrent disease, and four of these patients died within 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRT is a proven and reasonable effective approach in managing anal cancer. Observed recurrence and overall survival rates in this study resemble the published data. Despite newer methods of treatment being investigated, the treatment for anal SCC has not significantly changed in the past four decades and novel approaches are needed to further improve outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14745","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T10:01:01Z","timestamp":1535623261000},"page":"1013-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anal squamous cell carcinoma: are we improving outcomes?"],"prefix":"10.1111","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4712-6343","authenticated-orcid":false,"given":"Alicia","family":"Mackowski","sequence":"first","affiliation":[{"name":"Department of General Surgery, Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Levitt","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Makin","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Salama","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tan","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Penter","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Platell","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Unit St John of God Subiaco Hospital  Perth Western Australia Australia"},{"name":"Department of Surgery The University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02586980"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2527"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.2040"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.16.1914"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.4837"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.27.18_suppl.lba4009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.07.030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-017-2913-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.052"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.06.928"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553933"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.8085"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.07.007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9491-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9361-x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt368"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28045"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.034"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.04.011"},{"key":"e_1_2_6_22_1","first-page":"39","article-title":"Intensity\u2010modulated radiation therapy vs. 3D conformal radiation therapy for squamous cell carcinoma of the anal canal","volume":"6","author":"Chuong MD","year":"2013","journal-title":"Gastrointest. 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