{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:39:19Z","timestamp":1747183159520,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological studies have suggested that there may be ethnic variations in the prevalence of Hirschsprung disease (HD) but no study has systematically investigated this issue or potential ethnic variations in the extent of aganglionosis in HD. This study aimed to investigate this in a childhood population in New Zealand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentre national retrospective review was undertaken of all newly diagnosed cases of HD at each of the four paediatric surgical centres in New Zealand over a 16\u2010year period (January 2000 to December 2015). Original histological, radiological and operative reports were obtained and analysed. Self\u2010identified ethnicity was recorded from admission documents. Birth statistics were obtained from Statistics New Zealand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 246 cases of HD were identified. The prevalence of HD was 1:3790 live births for European, 1:6610 among M\u0101ori, 1:1834 among Pacific Peoples, 1:3847 among Asian and 1:5694 among Middle Eastern. The prevalence of HD was statistically significantly greater in Pacific Peoples (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005). The proportion of children with long\u2010segment HD was also significantly greater in Pacific and Asian populations than others (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). These findings were not due to differences in the proportion of familial cases of HD among the different populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence and phenotype of HD varies significantly between different ethnic groups within New Zealand. This may well be related to variations in the frequencies of HD\u2010associated gene mutations within these populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14857","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T18:25:19Z","timestamp":1538763919000},"page":"1246-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ethnic variations in the childhood prevalence of Hirschsprung disease in New Zealand"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-9966","authenticated-orcid":false,"given":"Kiarash","family":"Taghavi","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery and Urology Starship Children's Health  Auckland New Zealand"},{"name":"Department of Surgery The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Goddard","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Urology Starship Children's Health  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Urology Starship Children's Health  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Hobson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Christchurch Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-7064","authenticated-orcid":false,"given":"Spencer W.","family":"Beasley","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Christchurch Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasikumar","family":"Sankaran","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Waikato Hospital  Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Askar","family":"Kukkady","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Waikato Hospital  Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Wellington Children's Hospital  Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Stringer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Wellington Children's Hospital  Wellington New Zealand"},{"name":"Department of Paediatrics and Child Health University of Otago  Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.07.053"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-002-0842-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-4721-3_40"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6406.1671"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/13.4.479"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb12955.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320204"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90015-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.09.052"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23016"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2015.04.016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4608"},{"key":"e_1_2_7_14_1","unstructured":"TorfsCP.An epidemiological study of Hirschsprung disease in a multiracial California population. The Third International Meetings: Hirschsprung Disease and Related Neurocristopathies Evian France 1998."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(79)80145-1"},{"key":"e_1_2_7_16_1","unstructured":"Ethnic Group Profiles. Statistics New Zealand \u2013 Tatauranga Aotearoa. [Cited 15 Nov 2017.] Available from URL:http:\/\/www.stats.govt.nz\/Census\/2013-census\/profile-and-summary-reports\/ethnic-profiles.aspx"},{"key":"e_1_2_7_17_1","unstructured":"PoutasiK. Ministry of Health \u2013 Manat\u016b Hauora. Ethnicity data protocols for the health and disability sector 2004. 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