{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:43:52Z","timestamp":1768686232984,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372626"],"award-info":[{"award-number":["81372626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572975"],"award-info":[{"award-number":["81572975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The present study aimed to assess the risk factors of cholesterol and premalignancy in polypoid lesions of the gallbladder (PLGs) and to establish an appropriate treatment strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from patients who underwent cholecystectomy at the First Affiliated Hospital, School of Medicine, Zhejiang University, between January 2011 and July 2017, were collected retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1561 patients were included in the present study. The cohort comprised of 636 (40.7%) males and 925 (59.3%) females, with a mean age of 49.5 (range 16\u201388) years; 65.6% (1024\/1561) demonstrated cholesterol lesions in this cohort, among which cholesterol polyps accounted for 81.0%. Age younger than 50\u2009years and multiple number of polyps were found to be independent predictive variables for cholesterol lesions (odds ratio (OR) 3.461, 95% confidence interval (CI) 2.058\u20135.820, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and OR 3.321, 95% CI 1.988\u20135.547, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively). The presence of polyp growth was associated with premalignancy (OR 5.366, 95% CI 1.466\u201319.637, <jats:italic>P<\/jats:italic>\u2009=\u20090.011), and the presence of clinical symptoms indicated benign non\u2010cholesterol lesions (OR 0.368, 95% CI 0.153\u20130.885, <jats:italic>P<\/jats:italic>\u2009=\u20090.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the case of patients \u226550 years old with single asymptomatic polyp, cholecystectomy was recommended if the polyp presented growth at a rate above 3\u20134 mm within 6 months. If not, trimonthly ultrasound follow up was recommended, and clinicians should carefully assess the risk factors for premalignancy in PLGs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.14961","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:26:42Z","timestamp":1543537602000},"page":"388-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Strategy for discriminating cholesterol and premalignancy in polypoid lesions of the gallbladder: a single\u2010centre, retrospective cohort study"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-3944","authenticated-orcid":false,"given":"Tianchun","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province  Hangzhou China"},{"name":"State Key Laboratory and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital School of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongquan","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province  Hangzhou China"},{"name":"State Key Laboratory and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital School of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuancong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province  Hangzhou China"},{"name":"State Key Laboratory and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital School of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengdong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology, First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"Dong","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery Affiliated Tumor Hospital of Xinjiang Medical University  Xinjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province  Hangzhou China"},{"name":"State Key Laboratory and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital School of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.9.1247"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.6.1370"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-42302010000300001"},{"key":"e_1_2_8_5_1","first-page":"11569","article-title":"Polypoid lesions of the gallbladder: report of 160 cases with special reference to diagnosis and treatment in China","volume":"8","author":"Guo JJ","year":"2015","journal-title":"Int. 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