{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:31:13Z","timestamp":1756463473228},"reference-count":26,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Radical surgery with adjuvant therapy is now the standard treatment for locally advanced gastric cancer. However, the best regimen for adjuvant therapy remains controversial. We aim to determine the predictors of survival outcome of gastric cancer patients who underwent curative surgery with or without adjuvant therapy in our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients who received surgery for gastric cancer from years 2000 to 2015 were studied using a prospective gastric cancer database at the National University Hospital, Singapore.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 405 patients underwent radical gastrectomy with curative intent. Seventy\u2010eight percent received extended lymphadenectomy (\u2265D1). R0 resection was achieved in 377 patients (93%) with 30\u2010day mortality rate of 1.7%. There was no significant difference in the complication rate between D1 and extended lymphadenectomy group. One hundred and forty\u2010five patients (36%) received adjuvant therapy. With a median follow\u2010up of 5.9 years, the 5\u2010year disease\u2010free survival for stage I to IV patients were 78%, 58%, 27% and 9%, respectively. Among the 141 patients with known recurrences, the first site of recurrence was 38% distant, 24% locoregional, 20% peritoneal and the rest were multiple sites. Stage of disease, adjuvant therapy, extent of lymphadenectomy, post\u2010operative complication and approach of surgery were independent risk factors for long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stage of disease, adjuvant therapy, extent of lymphadenectomy, post\u2010operative complication and approach of surgery are significant predictors for long\u2010term survival. Adequate and safe surgery to allow adjuvant therapy should be the goal of all surgeons for our gastric cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.15011","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T04:01:53Z","timestamp":1548734513000},"page":"84-89","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictors of survival outcome following radical gastrectomy for gastric cancer"],"prefix":"10.1111","volume":"89","author":[{"given":"Su\u2010Ann","family":"Lui","sequence":"first","affiliation":[{"name":"Department of Surgery National University Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee Boon","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bee Choo","family":"Tai","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health National University of Singapore  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Peng","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Cancer Institute  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yar Soe","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiow Kong","family":"Ti","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asim","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy","family":"So","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800790404"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01360.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055531"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010187"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.5908"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61873-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320691"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0042-4"},{"key":"e_1_2_6_10_1","volume-title":"American Joint Committee on Cancer Staging Manual","author":"Edges SB","year":"2010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.30.4_suppl.89"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20823"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.026"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690243"},{"key":"e_1_2_6_15_1","unstructured":"Epidemiology & Disease Control Division. 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