{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:56:45Z","timestamp":1790978205457,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to establish compliance levels to prescription guidelines among Australian surgeons in the use of antibiotics in the surgical management of appendicitis. The secondary outcomes are predictors of post\u2010operative infective complications; surgical site infection (SSI) and intra\u2010abdominal abscess (IAA) at 30\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multi\u2010centre, prospective, observational study was conducted over a period of 2 months with a 30\u2010day follow\u2010up. Patients were eligible for recruitment if they underwent appendicectomy for suspected appendicitis. Antibiotics prescription practices were recorded and compared to national guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1189 patients were recruited across 27 centres; 1081 (92.1%) patients were given prophylactic antibiotics at the time of appendicectomy. Patients with gangrenous appendicitis were more likely to receive prophylactic antibiotics (98.9%); lower rates of use were seen in the non\u2010appendicitis group (85.7%). A total of 619 (53.3%) patients received antibiotics in the post\u2010operative period. Despite recommendations, 300 (44.3%) patients with simple appendicitis received post\u2010operative antibiotics. Only six (2.9%) patients with complicated appendicitis did not receive antibiotics. Overall, SSI and IAA rates were 1.9% and 2.7%, respectively. Aboriginal and Torres Strait Islanders (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) and patients with converted operations (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) were more likely to have a SSI. Patients with complicated appendicitis and those operated on by a consultant were more likely to increase the odds of IAA (odds ratio 3.8 and 5.1, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This broad\u2010based study shows mixed compliance with antibiotic guidelines in the surgical management of appendicitis in Australia. The use of post\u2010operative antibiotics in patients with simple appendicitis should be a target for antimicrobial stewardship programmes to prevent antibiotic over\u2010utilization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.15099","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T23:39:02Z","timestamp":1550533142000},"page":"251-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Variation in anti\u2010microbial prescription and complications post emergency appendicectomy in Australia: do we follow recommended guidelines?"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-3350","authenticated-orcid":false,"given":"Da Wei","family":"Thong","sequence":"first","affiliation":[{"name":"Department of Surgery Gold Coast University Hospital  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Gold Coast University Hospital  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Dobson","sequence":"additional","affiliation":[{"name":"Department of Surgery Gold Coast University Hospital  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Surgery Gold Coast University Hospital  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Surgery Gold Coast University Hospital  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"QUEST Collaboration","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Australian Institute of Health and Welfare.Admitted Patient Care 2015\u201316: Australian Hospital Statistics 2017. 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